Protein Info for H281DRAFT_05975 in Paraburkholderia bryophila 376MFSha3.1

Annotation: carbon-monoxide dehydrogenase large subunit

These analyses and tools can help you predict a protein's function, but be skeptical. For enzymes, over 10% of annotations from KEGG or SEED are probably incorrect. For other types of proteins, the error rates may be much higher. MetaCyc and Swiss-Prot have low error rates, but the best hits in these databases are often quite distant, so this protein's function may not be the same. TIGRFam has low error rates. Finally, many experimentally-characterized proteins are not in any of these databases. To find relevant papers, use PaperBLAST.

Protein Families and Features

1 50 100 150 200 250 300 350 400 450 500 550 600 650 700 750 813 PF01315: Ald_Xan_dh_C" amino acids 46 to 162 (117 residues), 72.8 bits, see alignment E=4.4e-24 PF02738: MoCoBD_1" amino acids 186 to 423 (238 residues), 213 bits, see alignment E=5.6e-67 PF20256: MoCoBD_2" amino acids 451 to 747 (297 residues), 231.3 bits, see alignment E=2.7e-72

Best Hits

KEGG orthology group: None (inferred from 56% identity to mes:Meso_0474)

Predicted SEED Role

"Carbon monoxide dehydrogenase large chain (EC 1.2.99.2) parolog without usual motifs" in subsystem CO Dehydrogenase (EC 1.2.99.2)

KEGG Metabolic Maps

Isozymes

Compare fitness of predicted isozymes for: 1.2.99.2

Use Curated BLAST to search for 1.2.99.2

Sequence Analysis Tools

PaperBLAST (search for papers about homologs of this protein)

Search CDD (the Conserved Domains Database, which includes COG and superfam)

Search structures

Predict protein localization: PSORTb (Gram-negative bacteria)

Predict transmembrane helices and signal peptides: Phobius

Check the current SEED with FIGfam search

Find homologs in fast.genomics or the ENIGMA genome browser

Find the best match in UniProt

Protein Sequence (813 amino acids)

>H281DRAFT_05975 carbon-monoxide dehydrogenase large subunit (Paraburkholderia bryophila 376MFSha3.1)
MSNQRTARSGQSGRRATNMEQTFKDASPGSLLGESVARLDAARFVSGRVDYSADLIPEGA
LHLAILRSVHACATIVSIDLSGALAMPGVVAGLTGEDAARMSDAMPPAMDLPAQGARGPL
QSRCLALEHATYFGQPVAALVATSVHDAQAALAKIRVEYEVQPATANARDALREGAPVVQ
PGWDTNLFVRDRIRSGDADAAFERAAHIARGELTVGPSTSAPMETLCYVAQWDARGERYT
LTGTFQNPHTSRWLIAVALRVKESQVRVIAPRIGGTFGLKMAGHPEEVLVALFSRITKRP
VAWVEERRETLLAGARSQHHSYEIAADEQGRLIGWRDRIMVDVGIIGAGHSWAMALVTPA
VFPTVYTIEHCDVECSLAITNRPPWQAIRGYGKEIGNLVLEHAIDRLARQTGMDPVELRR
RNLVAREALPRLLPSGLNVDSGDYPGGLEQLLTMFDYEQWQERASAARTSERRIGIGIAF
ELTPEGGARPGNFPNGYETSTVRMMPSGDVQVLTGVTSPGSGSDTGIAQMVAGELGLRAD
QVSVIEGDTDVTPLGTGNASSRALMYGGTAAYLAAQELRARLCQCAANLLGGTPEDISLR
DGHAWRESNGTRIAVAELALGAHLRPFTVAAGVTLPLEVTRSFAPQNVRVEPDVQGRIAT
YPTFSYSVHAAALELDMATGNSRLLDYAVVHDCGAMVNPALVEAQLRGAVVMGIGAALWE
LIKFDEHQRMITDRFKSYLLPRANDLPSIRVGHRVTLNPFHPLGMKGAGESGLGGALSAV
TNAVANALGDDARLTHVPATPARVMASLEERRA