Protein Info for H281DRAFT_05878 in Paraburkholderia bryophila 376MFSha3.1

Annotation: Multidrug efflux pump subunit AcrB

These analyses and tools can help you predict a protein's function, but be skeptical. For enzymes, over 10% of annotations from KEGG or SEED are probably incorrect. For other types of proteins, the error rates may be much higher. MetaCyc and Swiss-Prot have low error rates, but the best hits in these databases are often quite distant, so this protein's function may not be the same. TIGRFam has low error rates. Finally, many experimentally-characterized proteins are not in any of these databases. To find relevant papers, use PaperBLAST.

Protein Families and Features

1 100 200 300 400 500 600 700 800 900 1045 transmembrane" amino acids 17 to 38 (22 residues), see Phobius details amino acids 339 to 358 (20 residues), see Phobius details amino acids 363 to 384 (22 residues), see Phobius details amino acids 391 to 416 (26 residues), see Phobius details amino acids 431 to 454 (24 residues), see Phobius details amino acids 467 to 490 (24 residues), see Phobius details amino acids 528 to 548 (21 residues), see Phobius details amino acids 861 to 880 (20 residues), see Phobius details amino acids 886 to 908 (23 residues), see Phobius details amino acids 913 to 934 (22 residues), see Phobius details amino acids 963 to 983 (21 residues), see Phobius details amino acids 989 to 1013 (25 residues), see Phobius details PF00873: ACR_tran" amino acids 9 to 1011 (1003 residues), 478.2 bits, see alignment E=2.5e-147

Best Hits

KEGG orthology group: None (inferred from 91% identity to bcn:Bcen_1299)

Predicted SEED Role

No annotation

Sequence Analysis Tools

PaperBLAST (search for papers about homologs of this protein)

Search CDD (the Conserved Domains Database, which includes COG and superfam)

Search structures

Predict protein localization: PSORTb (Gram-negative bacteria)

Predict transmembrane helices and signal peptides: Phobius

Check the current SEED with FIGfam search

Find homologs in fast.genomics or the ENIGMA genome browser

Find the best match in UniProt

Protein Sequence (1045 amino acids)

>H281DRAFT_05878 Multidrug efflux pump subunit AcrB (Paraburkholderia bryophila 376MFSha3.1)
VSEGRFNLSALAVRERSITLFLICLISLAGLLSFFKLGRAEDPAFTIKVMTIVSVWPGAT
AQEMHDQVAEKIEKRMQELRWYDRTETYTRPGLAFTTLTLLDSTPPSEVQEEFYQARKKI
GDEAANLPAGVIGPMVNDEYADVTFALFALKARGEPQRLLVRDGETLRQRLLHVPGVKKV
NIIGEQAERIYVQFSHDRLATLGVSPQDVFAALNGQNALTPAGSVETKGPEVFIRLDGAF
DNLQKIRDTPVVVQGRTLKLSDIATVERGYEDPATFLIRNNGEPALLLGIVMRDGWNGLD
LGKALDSEVGAINGGLPLGMSLTKVTDQAVNIHSAVDEFMLKFFVALLVVMFVSFVSMGW
RAGLVVAAAVPLTLAVVFVVMAATGKNFDRITLGSLILALGLLVDDAIIAIEMMVVKMEE
GYSRVAASAYAWSHTAAPMLSGTLVTAVGFMPNGFARSTAGEYTSNMFWIVGIALIASWV
VAVVFTPYLGVKMLPDFKKVDGGHDAIYDTPRYNRFRQVLTRVIARKWLVAGSVVALFAL
AILGMGVVKKQFFPISDRPEVLVEVQMPYGTSISQTSAASQKVEAWLSGQKEARIVTAYV
GQGAPRFFLAMGPELPDPSFAKIVIRTDSQEERDALKARLRRAIADGLVPEARVRVTQLV
FGPYSPFPVAYRVTGPDPDKLRGIAAEVERVMQASPMMRTVNTDWGTRSPALHFVLQQDR
LQAVGLTSSAVAQQLQFLLTGTPVTAVREDIRTVQVIARSAGDVRLDPARLGDFTLAGAT
GQRIPLSQVGKVDVRMEEPISRWRDRVPTITVRGDIADNLQPPDVSTAITTQLQPIIAKL
PSGYRIEQAGSIEESAKATTAMLPLFPIMLAITLVIIIFQVRSISAMVMVFMTSPLGLIG
VVPTLILFGQPFGINALVGLIALSGILMRNTLILIGQIHQNENAGLDPFNAVVEATVQRA
RPVILTAMAAILAFIPLTHSVFWGTLAYTLIGGTFAGTILTLVFLPAMFAIWFKIRPGSP
AGAHKSPDHLSSRYEPITQDAVDAR