Protein Info for H281DRAFT_05877 in Paraburkholderia bryophila 376MFSha3.1

Annotation: RND family efflux transporter, MFP subunit

These analyses and tools can help you predict a protein's function, but be skeptical. For enzymes, over 10% of annotations from KEGG or SEED are probably incorrect. For other types of proteins, the error rates may be much higher. MetaCyc and Swiss-Prot have low error rates, but the best hits in these databases are often quite distant, so this protein's function may not be the same. TIGRFam has low error rates. Finally, many experimentally-characterized proteins are not in any of these databases. To find relevant papers, use PaperBLAST.

Protein Families and Features

1 50 100 150 200 250 300 371 signal peptide" amino acids 1 to 24 (24 residues), see Phobius details TIGR01730: efflux transporter, RND family, MFP subunit" amino acids 40 to 357 (318 residues), 201.5 bits, see alignment E=8.6e-64 PF16576: HlyD_D23" amino acids 59 to 261 (203 residues), 47.5 bits, see alignment E=2.2e-16 PF13533: Biotin_lipoyl_2" amino acids 67 to 108 (42 residues), 31.7 bits, see alignment 1.6e-11 PF13437: HlyD_3" amino acids 173 to 261 (89 residues), 39.5 bits, see alignment E=1.2e-13

Best Hits

KEGG orthology group: None (inferred from 90% identity to bph:Bphy_3547)

Predicted SEED Role

"Probable Co/Zn/Cd efflux system membrane fusion protein" in subsystem Cobalt-zinc-cadmium resistance

Sequence Analysis Tools

PaperBLAST (search for papers about homologs of this protein)

Search CDD (the Conserved Domains Database, which includes COG and superfam)

Search structures

Predict protein localization: PSORTb (Gram-negative bacteria)

Predict transmembrane helices and signal peptides: Phobius

Check the current SEED with FIGfam search

Find homologs in fast.genomics or the ENIGMA genome browser

Find the best match in UniProt

Protein Sequence (371 amino acids)

>H281DRAFT_05877 RND family efflux transporter, MFP subunit (Paraburkholderia bryophila 376MFSha3.1)
MFSRRLATSALACALPFALTACGEKAPSDPRTEVPLVRTAIVQRAVPASRSFTGTVAARV
QSDLGFRVSGKVLERRVDAGQTVRRGQLLMRLDPIDLKLAAQARQEAVTAARARAQQTAQ
DEARYRDLRGTGAISASAYDQAKAAADAAKAQLSAAEADADVARNATGYADLVADGDGVV
METLAEPGQVVSAGQPVVRLAHAGRREAVIQLPETLRPVIGSVAQAALFGDGGASVPATL
RQLSDTADPRTRTFEARYVLQGALADAPLGATVTIEIPDTRVALQDGMQVPIGAVLDAGK
GSGVWVVNGEPAKVAWRPVTVLHLGDDSARVSGKLEQGDRVIALGAHLLREGEQVRVSGQ
AVAMANEGARP