Protein Info for H281DRAFT_05826 in Paraburkholderia bryophila 376MFSha3.1

Annotation: glutamine--fructose-6-phosphate transaminase

These analyses and tools can help you predict a protein's function, but be skeptical. For enzymes, over 10% of annotations from KEGG or SEED are probably incorrect. For other types of proteins, the error rates may be much higher. MetaCyc and Swiss-Prot have low error rates, but the best hits in these databases are often quite distant, so this protein's function may not be the same. TIGRFam has low error rates. Finally, many experimentally-characterized proteins are not in any of these databases. To find relevant papers, use PaperBLAST.

Protein Families and Features

• TIGR01135: glutamine-fructose-6-phosphate transaminase (isomerizing)
  • amino acids 2 to 605 (604 residues), 816.1 bits, E=9.7e-250
• PF13522: GATase_6
  • amino acids 67 to 189 (123 residues), 76.7 bits, E=2.7e-25
• PF13537: GATase_7
  • amino acids 81 to 191 (111 residues), 58.9 bits, E=7.5e-20
• PF01380: SIS
  • amino acids 286 to 413 (128 residues), 94.1 bits, E=9.3e-31
  • amino acids 458 to 585 (128 residues), 85.9 bits, E=3.3e-28

Best Hits

Swiss-Prot: 75% identical to GLMS_RALSO: Glutamine--fructose-6-phosphate aminotransferase [isomerizing] (glmS) from Ralstonia solanacearum (strain GMI1000)

KEGG orthology group: K00820, glucosamine--fructose-6-phosphate aminotransferase (isomerizing) [EC: 2.6.1.16] (inferred from 97% identity to bug:BC1001_3330)

Predicted SEED Role

"Glucosamine--fructose-6-phosphate aminotransferase [isomerizing] (EC 2.6.1.16)" in subsystem Sialic Acid Metabolism or UDP-N-acetylmuramate from Fructose-6-phosphate Biosynthesis (EC 2.6.1.16)

MetaCyc Pathways

• O-antigen building blocks biosynthesis (E. coli) (10/11 steps found)
• UDP-N-acetyl-D-glucosamine biosynthesis I (5/5 steps found)
• UDP-N-acetyl-D-glucosamine biosynthesis II (4/6 steps found)
• chitin biosynthesis (6/9 steps found)
• UDP-N-acetyl-D-galactosamine biosynthesis III (2/6 steps found)
• CMP-legionaminate biosynthesis I (2/10 steps found)
• superpathway of mycolyl-arabinogalactan-peptidoglycan complex biosynthesis (12/33 steps found)
• superpathway of UDP-N-acetylglucosamine-derived O-antigen building blocks biosynthesis (5/24 steps found)

KEGG Metabolic Maps

• Aminosugars metabolism
• Glutamate metabolism
• Nucleotide sugars metabolism

Isozymes

Compare fitness of predicted isozymes for: 2.6.1.16

Use Curated BLAST to search for 2.6.1.16

Sequence Analysis Tools

See A0A2Z5MEW9 at UniProt or InterPro

Protein Sequence (605 amino acids)

>H281DRAFT_05826 glutamine--fructose-6-phosphate transaminase (Paraburkholderia bryophila 376MFSha3.1)
MCGIVGAAAQRNIVPVLIEGLRRLEYRGYDSCGVAVLGEGGPARARSVARVADLDDQVRD
SHLGGITGIAHTRWATHGAPVTDNAHPIFSKDALALVHNGIIENYESLRETLRDKGYTFV
SQTDTEVIAHLIHSLYRGDLFAAVREAVAQLHGAYAIAVLHKDQPHTVVGARQGSPLVVG
LGDGENFLASDALALAGSTERFIFLEEGDVCELTLEGVRIADREGNEVRREVRQVAAYGG
AVELGPYRHFMQKEIFEQPRAISDTIPQSDSFEASLFGESAGNVFADIDNLLILACGTSY
YSGLTAKYWLESIAKIPTQVEIASEYRYRESVPNPRSLVVVISQSGETADTLAALKHAQA
LGHRHTLAVCNVGTSAMVRQTELAFLTHAGREIGVASTKAFTTQLVALFVLAVTLAKQRG
RVSPEQETEYLRQLRHLPAALNSVLALEPQIIAWSEEFSRKEHALFLGRGMHYPIALEGA
LKLKEISYIHAEAYPAGELKHGPLALVTEAMPVVTVAPNDALLEKLKSNIQEVRARGGQL
YVFADADTKIVNDEGIHVIRMPEHYGLLSPILHVVPLQLLAYHTACARGTDVDKPRNLAK
SVTVE