Protein Info for H281DRAFT_05794 in Paraburkholderia bryophila 376MFSha3.1
Annotation: Choline dehydrogenase
These analyses and tools can help you predict a protein's function, but be skeptical. For enzymes, over 10% of annotations from KEGG or SEED are probably incorrect. For other types of proteins, the error rates may be much higher. MetaCyc and Swiss-Prot have low error rates, but the best hits in these databases are often quite distant, so this protein's function may not be the same. TIGRFam has low error rates. Finally, many experimentally-characterized proteins are not in any of these databases. To find relevant papers, use PaperBLAST.
Protein Families and Features
Best Hits
Swiss-Prot: 48% identical to ALKJ_PSEOL: Alcohol dehydrogenase [acceptor] (alkJ) from Pseudomonas oleovorans
KEGG orthology group: None (inferred from 90% identity to bug:BC1001_3363)MetaCyc: 48% identical to octanol dehydrogenase (Pseudomonas oleovorans)
1.1.99.-
Predicted SEED Role
"Choline dehydrogenase (EC 1.1.99.1)" in subsystem Choline and Betaine Uptake and Betaine Biosynthesis (EC 1.1.99.1)
MetaCyc Pathways
- choline-O-sulfate degradation (3/3 steps found)
- choline degradation I (2/2 steps found)
- glycine betaine biosynthesis I (Gram-negative bacteria) (2/2 steps found)
- glycine betaine biosynthesis II (Gram-positive bacteria) (2/2 steps found)
- octane oxidation (4/5 steps found)
KEGG Metabolic Maps
Isozymes
Compare fitness of predicted isozymes for: 1.1.99.1
Use Curated BLAST to search for 1.1.99.1
Sequence Analysis Tools
PaperBLAST (search for papers about homologs of this protein)
Search CDD (the Conserved Domains Database, which includes COG and superfam)
Predict protein localization: PSORTb (Gram-negative bacteria)
Predict transmembrane helices and signal peptides: Phobius
Check the current SEED with FIGfam search
Find homologs in fast.genomics or the ENIGMA genome browser
Find the best match in UniProt
Protein Sequence (550 amino acids)
>H281DRAFT_05794 Choline dehydrogenase (Paraburkholderia bryophila 376MFSha3.1) MEYDYIIVGAGSGGCALASRLADDCPDATIALVEAGPHTNRNLLVNMPVGVAAVVPNKLK TNYGYLTTPQPGLAGRQGYQPRGRGFGGSSAINAMIYTRGHPLDYDEWAESGCDGWSWHD VLPYFRRAEGNERGADAWHGDSGPLTVSDLRYRNPFSRRFVQAAIEAGYKPNDDFNGPDQ EGIGFYQVTQRDGRRCSVARAYVYDRERANLHTIADATVLRVVFEQKRACGVEIVRGGRR EMLKARAEVVVAAGAFNSPQLLMCSGVGPAAHLQAHGIEVLHDAPEVGQNLIDHVDFTIN KRVSSIEPTGFSVRGIGRMVPQFATFIRHGRGMLSSNVAEAGGFLKSKPTLERPDLQLHF CAALVDDHNRHMHWGHGYSLHVCVLRPFSRGTVTLASADARAAPVIDPRFFSDSRDLDLL VEGVQMARRILDAPSLALHGGRELYTRPGQTDAQLREAIARHADTIYHPVATCRMGGDAA SVVDPQLRVRGVTGLRIVDASVMPTLIGGNTNAPTVMIGERAAELIAASRRKPHTVTIQA PAMAPAGNAA