Protein Info for H281DRAFT_05663 in Paraburkholderia bryophila 376MFSha3.1

Annotation: histidine triad (HIT) family protein

These analyses and tools can help you predict a protein's function, but be skeptical. For enzymes, over 10% of annotations from KEGG or SEED are probably incorrect. For other types of proteins, the error rates may be much higher. MetaCyc and Swiss-Prot have low error rates, but the best hits in these databases are often quite distant, so this protein's function may not be the same. TIGRFam has low error rates. Finally, many experimentally-characterized proteins are not in any of these databases. To find relevant papers, use PaperBLAST.

Protein Families and Features

1 50 121 PF11969: DcpS_C" amino acids 6 to 112 (107 residues), 88.9 bits, see alignment E=3.4e-29 PF01230: HIT" amino acids 15 to 113 (99 residues), 92.4 bits, see alignment E=2.4e-30

Best Hits

Swiss-Prot: 50% identical to HITA_NEIGO: Protein HitA (hitA) from Neisseria gonorrhoeae

KEGG orthology group: K02503, Hit-like protein involved in cell-cycle regulation (inferred from 95% identity to bge:BC1002_2809)

MetaCyc: 47% identical to purine nucleoside phosphoramidase (Escherichia coli K-12 substr. MG1655)
3.9.1.-

Predicted SEED Role

"FIG146285: Diadenosine tetraphosphate (Ap4A) hydrolase and other HIT family hydrolases"

Sequence Analysis Tools

PaperBLAST (search for papers about homologs of this protein)

Search CDD (the Conserved Domains Database, which includes COG and superfam)

Search structures

Predict protein localization: PSORTb (Gram-negative bacteria)

Predict transmembrane helices and signal peptides: Phobius

Check the current SEED with FIGfam search

Find homologs in fast.genomics or the ENIGMA genome browser

See A0A2Z5MG19 at UniProt or InterPro

Protein Sequence (121 amino acids)

>H281DRAFT_05663 histidine triad (HIT) family protein (Paraburkholderia bryophila 376MFSha3.1)
MSHDPNCLFCKIAAGEIPSTKVHEDDEFVAFRDIRPAAETHVLVIPRKHIATLSDCTESD
APLLGRMLVLTARLADQLGVAYTGGETGFRTVINTGPGGGQEVYHLHAHILAGPRPWQRM
G