Protein Info for H281DRAFT_05506 in Paraburkholderia bryophila 376MFSha3.1

Annotation: N-acetylglucosamine 6-phosphate deacetylase (EC 3.5.1.25)

These analyses and tools can help you predict a protein's function, but be skeptical. For enzymes, over 10% of annotations from KEGG or SEED are probably incorrect. For other types of proteins, the error rates may be much higher. MetaCyc and Swiss-Prot have low error rates, but the best hits in these databases are often quite distant, so this protein's function may not be the same. TIGRFam has low error rates. Finally, many experimentally-characterized proteins are not in any of these databases. To find relevant papers, use PaperBLAST.

Protein Families and Features

• TIGR00221: N-acetylglucosamine-6-phosphate deacetylase
  • amino acids 37 to 362 (326 residues), 235.4 bits, E=5.1e-74
• PF01979: Amidohydro_1
  • amino acids 40 to 350 (311 residues), 43.2 bits, E=3.3e-15

Best Hits

KEGG orthology group: None (inferred from 64% identity to bgd:bgla_1g24560)

Predicted SEED Role

"N-acetylglucosamine-6-phosphate deacetylase (EC 3.5.1.25)" in subsystem Chitin and N-acetylglucosamine utilization or Sialic Acid Metabolism or UDP-N-acetylmuramate from Fructose-6-phosphate Biosynthesis (EC 3.5.1.25)

MetaCyc Pathways

• N-acetylglucosamine degradation II (3/3 steps found)
• N-acetylglucosamine degradation I (2/2 steps found)
• superpathway of N-acetylneuraminate degradation (16/22 steps found)
• peptidoglycan recycling I (10/14 steps found)
• D-galactosamine and N-acetyl-D-galactosamine degradation (1/4 steps found)
• superpathway of N-acetylglucosamine, N-acetylmannosamine and N-acetylneuraminate degradation (2/6 steps found)
• N-acetyl-D-galactosamine degradation (1/5 steps found)
• chitin derivatives degradation (3/8 steps found)

KEGG Metabolic Maps

• Aminosugars metabolism
• Galactose metabolism
• Nucleotide sugars metabolism

Isozymes

Compare fitness of predicted isozymes for: 3.5.1.25

Use Curated BLAST to search for 3.5.1.25

Protein Sequence (376 amino acids)

>H281DRAFT_05506 N-acetylglucosamine 6-phosphate deacetylase (EC 3.5.1.25) (Paraburkholderia bryophila 376MFSha3.1)
MKNILTPKGWVLGRVVVDAAGLIARIEGSPVTSPLLAAGYVLPGFIDLHVHGGGGTDLMD
GETAACVVAKTHAEYGTTSFLATTMTAPEDDLRVATGHLGAAIRKPRGPGQSRILGVHLE
GPFLNANKRGSQPAHTRCAAPAELDELLNIAHVRLVTLAPEIEGQLAIIRKLVERGIRVQ
LGHSTGTYEQGLAALQCGATGFAHLFNAMSGMHHRDPGIVGVAFAHAEYAEMIPDLLHVH
PGAVKAAFRAIPKLYCITDSCSAVGMGEGEFTLGAQKVFRRRCESGVRLADGTLAASTLT
MDEALRNLVSLGMTIADASDRLSRFPADFLGLQDRGRLVPGAWGDYVALSQNLALEEVCI
EGEHVKPASTISVEQP