Protein Info for H281DRAFT_05311 in Paraburkholderia bryophila 376MFSha3.1

Annotation: MFS transporter, ACS family, hexuronate transporter

These analyses and tools can help you predict a protein's function, but be skeptical. For enzymes, over 10% of annotations from KEGG or SEED are probably incorrect. For other types of proteins, the error rates may be much higher. MetaCyc and Swiss-Prot have low error rates, but the best hits in these databases are often quite distant, so this protein's function may not be the same. TIGRFam has low error rates. Finally, many experimentally-characterized proteins are not in any of these databases. To find relevant papers, use PaperBLAST.

Protein Families and Features

1 50 100 150 200 250 300 350 400 432 signal peptide" amino acids 1 to 32 (32 residues), see Phobius details transmembrane" amino acids 47 to 68 (22 residues), see Phobius details amino acids 75 to 95 (21 residues), see Phobius details amino acids 101 to 121 (21 residues), see Phobius details amino acids 134 to 158 (25 residues), see Phobius details amino acids 164 to 183 (20 residues), see Phobius details amino acids 228 to 249 (22 residues), see Phobius details amino acids 264 to 286 (23 residues), see Phobius details amino acids 303 to 322 (20 residues), see Phobius details amino acids 327 to 348 (22 residues), see Phobius details amino acids 361 to 384 (24 residues), see Phobius details amino acids 391 to 411 (21 residues), see Phobius details PF07690: MFS_1" amino acids 15 to 291 (277 residues), 163.8 bits, see alignment E=2.7e-52 amino acids 300 to 416 (117 residues), 39.5 bits, see alignment E=1.7e-14

Best Hits

Swiss-Prot: 57% identical to EXUT_ECOLI: Hexuronate transporter (exuT) from Escherichia coli (strain K12)

KEGG orthology group: K08191, MFS transporter, ACS family, hexuronate transporter (inferred from 96% identity to bug:BC1001_5590)

MetaCyc: 57% identical to hexuronate transporter (Escherichia coli K-12 substr. MG1655)
TRANS-RXN-123; TRANS-RXN-35

Predicted SEED Role

"Hexuronate transporter" in subsystem Alginate metabolism or D-Galacturonate and D-Glucuronate Utilization

Sequence Analysis Tools

PaperBLAST (search for papers about homologs of this protein)

Search CDD (the Conserved Domains Database, which includes COG and superfam)

Search structures

Predict protein localization: PSORTb (Gram-negative bacteria)

Predict transmembrane helices and signal peptides: Phobius

Check the current SEED with FIGfam search

Find homologs in fast.genomics or the ENIGMA genome browser

See A0A2Z5MJE7 at UniProt or InterPro

Protein Sequence (432 amino acids)

>H281DRAFT_05311 MFS transporter, ACS family, hexuronate transporter (Paraburkholderia bryophila 376MFSha3.1)
MKIKGIRWWMVSLVAAGLIINYLARNTLSVAAPTLMKDLHITTEQYAHVVVAWQLCYAFM
QPVAGFLLDTVGTKIGFAAFALAWSLACAAAAWSTGWRSLAFFRGLLGIAEAAGIPAGVK
ATSEWFPAKERSVAIGWFNIGSSIGALLAPPLVVWALLHGQWQLAFVIVGVAGIIWSVVW
MVLYKHPRNQKLLGDGERDYILSGQEAKHSDAGAPKRSWSAMLRSRDFWAIGIPRILSEP
AWQTFNAWIPLYMMTERHMNLKEIALYAWMPFLAADIGCVLGGYLSPLFHKYAKVSLFTS
RKMVFVVGALCMIGPACVGLVASPYVAVALLCVGGFAHQTLSGALYAITSDMFGKNEVAT
ATGMGGMAGYLGAAAFTALFGVLVTQVGYSPLFVVLAVFDIIAAAVVCLLAKSADRTAEP
RWSQPGSAVTAK