Protein Info for H281DRAFT_05206 in Paraburkholderia bryophila 376MFSha3.1

Annotation: chloride channel protein, CIC family

These analyses and tools can help you predict a protein's function, but be skeptical. For enzymes, over 10% of annotations from KEGG or SEED are probably incorrect. For other types of proteins, the error rates may be much higher. MetaCyc and Swiss-Prot have low error rates, but the best hits in these databases are often quite distant, so this protein's function may not be the same. TIGRFam has low error rates. Finally, many experimentally-characterized proteins are not in any of these databases. To find relevant papers, use PaperBLAST.

Protein Families and Features

1 50 100 150 200 250 300 350 400 450 500 550 607 transmembrane" amino acids 12 to 35 (24 residues), see Phobius details amino acids 55 to 73 (19 residues), see Phobius details amino acids 101 to 120 (20 residues), see Phobius details amino acids 170 to 187 (18 residues), see Phobius details amino acids 193 to 214 (22 residues), see Phobius details amino acids 217 to 219 (3 residues), see Phobius details amino acids 222 to 244 (23 residues), see Phobius details amino acids 264 to 283 (20 residues), see Phobius details amino acids 304 to 321 (18 residues), see Phobius details amino acids 341 to 362 (22 residues), see Phobius details amino acids 370 to 392 (23 residues), see Phobius details amino acids 400 to 423 (24 residues), see Phobius details amino acids 430 to 449 (20 residues), see Phobius details PF00654: Voltage_CLC" amino acids 109 to 450 (342 residues), 314.9 bits, see alignment E=7.1e-98 PF00571: CBS" amino acids 484 to 532 (49 residues), 20.2 bits, see alignment 6.4e-08 amino acids 546 to 600 (55 residues), 18 bits, see alignment 2.9e-07

Best Hits

KEGG orthology group: K03281, chloride channel protein, CIC family (inferred from 96% identity to bug:BC1001_1499)

Predicted SEED Role

"Chloride channel protein"

Sequence Analysis Tools

PaperBLAST (search for papers about homologs of this protein)

Search CDD (the Conserved Domains Database, which includes COG and superfam)

Search structures

Predict protein localization: PSORTb (Gram-negative bacteria)

Predict transmembrane helices and signal peptides: Phobius

Check the current SEED with FIGfam search

Find homologs in fast.genomics or the ENIGMA genome browser

See A0A2Z5MH33 at UniProt or InterPro

Protein Sequence (607 amino acids)

>H281DRAFT_05206 chloride channel protein, CIC family (Paraburkholderia bryophila 376MFSha3.1)
MPGSAPASSSGRAAVVVCAFLTFHHACTVDVLSFLLKLRTRAHDLFRLSDAHTMLVWSVV
VGVAGAFATIAFRQGIELLQLLVAGKSGSFVEMARSLPWTVRIWLPAAGGLVAGFLLLIA
QRHADKCNHIDYMEAVAIGDGVVPVKLSLWRSLSSLFTISSGGSIGREGPMVQLAALAAS
LIGRWVHFDPPRLRLLVACGAAAGITSAYNAPIAGAFFVTEIVLGSIAMESFGPVVVAAV
VANITMREFAGYKPPYEMPVFPPVAGIEVLLFVALGLLCGAAAPQFLRLLDGSKKLFRKL
PLPLPARLALGGLVVGILSVWTPEVWGNGYSVVNSVLHSPWTWTALVVVLVFKLVATAAT
AGSGAVGGVFTPTLFVGAVVGSLFGLAMHALWPHGTSAPFAYAMVGMGAFLAGATQAPLM
AILMIFEMTLSYQVVLPLMLSCVVAYFVSRAIGKTSMYEITLRRNQEEMERTRLRATQMR
ELIRPAQTVVPPNATVHDMTRVFLEYPVKYLYVANESGAFLGVVALKDITSDLLDKRDTS
TRTAADYLQPHFDVLTPDMPLGVALQHFMAFQGERLPVVESAAHPRLAGVVYKTSLLDAY
FRMNPTR