Protein Info for H281DRAFT_05197 in Paraburkholderia bryophila 376MFSha3.1

Annotation: Multidrug efflux pump subunit AcrB

These analyses and tools can help you predict a protein's function, but be skeptical. For enzymes, over 10% of annotations from KEGG or SEED are probably incorrect. For other types of proteins, the error rates may be much higher. MetaCyc and Swiss-Prot have low error rates, but the best hits in these databases are often quite distant, so this protein's function may not be the same. TIGRFam has low error rates. Finally, many experimentally-characterized proteins are not in any of these databases. To find relevant papers, use PaperBLAST.

Protein Families and Features

1 100 200 300 400 500 600 700 800 900 1042 transmembrane" amino acids 21 to 40 (20 residues), see Phobius details amino acids 343 to 362 (20 residues), see Phobius details amino acids 369 to 388 (20 residues), see Phobius details amino acids 400 to 420 (21 residues), see Phobius details amino acids 432 to 459 (28 residues), see Phobius details amino acids 472 to 495 (24 residues), see Phobius details amino acids 536 to 556 (21 residues), see Phobius details amino acids 869 to 887 (19 residues), see Phobius details amino acids 894 to 915 (22 residues), see Phobius details amino acids 921 to 942 (22 residues), see Phobius details amino acids 967 to 985 (19 residues), see Phobius details amino acids 996 to 1017 (22 residues), see Phobius details PF00873: ACR_tran" amino acids 16 to 1018 (1003 residues), 520.4 bits, see alignment E=4.4e-160

Best Hits

KEGG orthology group: None (inferred from 95% identity to bpy:Bphyt_2293)

Predicted SEED Role

"Acriflavin resistance protein" in subsystem Multidrug Resistance Efflux Pumps

Sequence Analysis Tools

PaperBLAST (search for papers about homologs of this protein)

Search CDD (the Conserved Domains Database, which includes COG and superfam)

Search structures

Predict protein localization: PSORTb (Gram-negative bacteria)

Predict transmembrane helices and signal peptides: Phobius

Check the current SEED with FIGfam search

Find homologs in fast.genomics or the ENIGMA genome browser

See A0A2Z5MCE1 at UniProt or InterPro

Protein Sequence (1042 amino acids)

>H281DRAFT_05197 Multidrug efflux pump subunit AcrB (Paraburkholderia bryophila 376MFSha3.1)
MSTTHEEGRFNLSAWALRHQALVVFLIALATAFGILAYTRLAQSEDPPFTFRVMVIRTFW
PGATARQVQEQVTDRIGRKLQETPAIDFVRSYSRPGESLMFFTMKDSAPVKDVPETWYQV
RKKVGDIAATLPQGIQGPFFNDEFGDVYTNIYTLEGDGFSPAQLHDYADQLRTVLLRVPG
VAKVDYFGDPDQHIYIEITNTQLTRLGISPQQLGQAINSQNAVSQAGTLTTTDDRVFVRP
SGQFKDVTALADTLIRINGRSFRLGDIATIKRGYDDPVVTQMRAGGQAVLGIGVTMQPGG
DVIRLGKALDAEMVRLRKALPVGLQLTEVSSMPHAVAHSVDDFLEAVAEAVAIVLVVSLV
SLGVRTGMVVVISIPVVLAVTALCMYLFDIGLHKVSLGTLVLALGLLVDDAIIAVEMMAV
KLEQGWSRTRAAAFAYTSTAFPMLTGTLVTVSGFLPIALAKSSTGEYTRSIFEVSAIALI
ASWLAAVVLIPLLGYHLLPERKRAAHEADDHEHDIYDTRFYSRLRGWIGWCIERRFVVLA
ITVVLFVLAMAGFTLVPQQFFPSSDRPELLVDVRLPEGASFNATLREAQRLEKVLVGRPE
IDHTVDFVGTGAPRFYLPLDQQLTQPNFAQFVITAKSVKDREKLAQWLEPELRNNFPAIR
TRLSRLENGPPVGYPVQFRVSGDDIATVRSIAERVAATLRSDHGTRNVQFDWDEPAERSV
RFEVDQKKARELGVSSDDISSFLAMTLSGYTVTQYRERDKLISVDLRAPKAERVDPAKLL
TLAMPTPNGAVPLGTLGHLRNDLEYGVIWERDRQPTITVQSDVAPGAQGIDVTHAVDKAL
GPIRANLPVGYRIQIGGSVEESGKGQTSINAQMPIMIIAVLTLLMIQLQSFARVLMVVLT
APLGLIGVVFTLLLFGQPFGFVAMLGVIAMFGIIMRNSVILVDQIEQDIASGHKRFDAIV
GATVRRFRPITLTAAAAVLALIPLLRSNFFGPMATALMGGITSATVLTLFYLPALYAMSF
RVRNDEREPQTPSASGAAHTGN