Protein Info for H281DRAFT_05104 in Paraburkholderia bryophila 376MFSha3.1

Annotation: bacterial translation initiation factor 2 (bIF-2)

These analyses and tools can help you predict a protein's function, but be skeptical. For enzymes, over 10% of annotations from KEGG or SEED are probably incorrect. For other types of proteins, the error rates may be much higher. MetaCyc and Swiss-Prot have low error rates, but the best hits in these databases are often quite distant, so this protein's function may not be the same. TIGRFam has low error rates. Finally, many experimentally-characterized proteins are not in any of these databases. To find relevant papers, use PaperBLAST.

Protein Families and Features

1 50 100 150 200 250 300 350 400 450 500 550 600 650 700 750 800 850 900 950 981 PF04760: IF2_N" amino acids 2 to 51 (50 residues), 27.2 bits, see alignment 8.1e-10 amino acids 405 to 455 (51 residues), 55.5 bits, see alignment 1.2e-18 PF08364: IF2_assoc" amino acids 61 to 99 (39 residues), 54.7 bits, see alignment (E = 2.8e-18) TIGR00487: translation initiation factor IF-2" amino acids 400 to 981 (582 residues), 872.6 bits, see alignment E=1.6e-266 TIGR00231: small GTP-binding protein domain" amino acids 484 to 640 (157 residues), 107.5 bits, see alignment E=6.2e-35 PF01926: MMR_HSR1" amino acids 486 to 591 (106 residues), 37.4 bits, see alignment E=7.2e-13 PF00009: GTP_EFTU" amino acids 486 to 641 (156 residues), 126.6 bits, see alignment E=2.7e-40 PF11987: IF-2" amino acids 757 to 871 (115 residues), 148.9 bits, see alignment E=1.8e-47

Best Hits

Swiss-Prot: 87% identical to IF2_BURM1: Translation initiation factor IF-2 (infB) from Burkholderia multivorans (strain ATCC 17616 / 249)

KEGG orthology group: K02519, translation initiation factor IF-2 (inferred from 92% identity to bpy:Bphyt_1632)

Predicted SEED Role

"Translation initiation factor 2" in subsystem NusA-TFII Cluster or Translation initiation factors eukaryotic and archaeal or Universal GTPases

Sequence Analysis Tools

PaperBLAST (search for papers about homologs of this protein)

Search CDD (the Conserved Domains Database, which includes COG and superfam)

Search structures

Predict protein localization: PSORTb (Gram-negative bacteria)

Predict transmembrane helices and signal peptides: Phobius

Check the current SEED with FIGfam search

Find homologs in fast.genomics or the ENIGMA genome browser

See A0A2Z5MD87 at UniProt or InterPro

Protein Sequence (981 amino acids)

>H281DRAFT_05104 bacterial translation initiation factor 2 (bIF-2) (Paraburkholderia bryophila 376MFSha3.1)
MASNNVAQFAAELKMPAGVLLEQLQAAGVTKASEADSLSETDKARLLDHLRKSHGSTDAD
KRKITLTKRHTSEIKQSDATGKARTIQVEVRKKRTFVRRDETSADGGDASNHVAEAAEVD
DLELQRREEEARHAAELLEQQAQELKARQEQLEREEAERQAREQAAEAERRRAEEEAAKK
RAAAAAEAAAREKAQPAPQVAKVQTAPAKPAEPVVAKDTEQDDERAAAERAAQREAAKKA
EDAARQAAEKARAEQEEIAKRRAAAEAEARAIREMMNTPRKAQVKAPEPAPKPAEPAKAA
EAKGTLHKPARPAGEAPARPAARKSAAAAPAATTTPSVGDKKKPGGKGGWQDDAAKRRGI
KTRGDTSGGVDRGWRGGPKGRGKHQDQNTTFQAPTEPIVREVHVPETITVADLAHKMAVK
ASEVIKSMMKLGQMVTINQMLDQETAMIIVEELGHHAVAAKLDDPEAMLVEGEVSDAEAL
PRPPVVTVMGHVDHGKTSLLDYIRRAKVAAGEAGGITQHIGAYHVETPRGVITFLDTPGH
EAFTAMRARGAKATDIVILVVAADDGVMPQTKEAIAHAKAGGVPLVVAINKIDKPDANPD
RVKQELVAEGVVPEEYGGDSPFVSVSAKTGAGIDDLLENVLLQAEVLELKAPVEAPAKGL
VIEAKLDKGKGPVATILVQSGTLNRGDVVLAGSAYGRVRAMLDETGKPTKSAGPSIPVEI
QGLSEVPQAGEEVIVMPDDRKAREVALFRQGKFRDVKLAKQQAAKLENMLEQMGEGEVAY
MPLIVKADVQGSQEALVQSLLKLSTDEVRVQIVHGAVGGISESDVNLATASKAVIIGFNT
RADAQARKLAEANGVDIRYYNIIYDAVDEVKAAMSGMLAPEKREVVTGTVEVRQVFKVPK
IGAVAGCMVTDGYVKRSSSVRVLRNNVVIFTGELDSLKRFKDDVKEVRQGFECGMSIKNF
NDIVEGDQFEVFEVTEVARTL