Protein Info for H281DRAFT_04849 in Paraburkholderia bryophila 376MFSha3.1

Annotation: UDP-glucose 4-epimerase

These analyses and tools can help you predict a protein's function, but be skeptical. For enzymes, over 10% of annotations from KEGG or SEED are probably incorrect. For other types of proteins, the error rates may be much higher. MetaCyc and Swiss-Prot have low error rates, but the best hits in these databases are often quite distant, so this protein's function may not be the same. TIGRFam has low error rates. Finally, many experimentally-characterized proteins are not in any of these databases. To find relevant papers, use PaperBLAST.

Protein Families and Features

• PF04321: RmlD_sub_bind
  • amino acids 3 to 260 (258 residues), 69.6 bits, E=8.5e-23
• PF01370: Epimerase
  • amino acids 4 to 224 (221 residues), 130 bits, E=3.6e-41
• PF01073: 3Beta_HSD
  • amino acids 5 to 221 (217 residues), 78.6 bits, E=1.5e-25
• PF16363: GDP_Man_Dehyd
  • amino acids 6 to 308 (303 residues), 69.8 bits, E=1.1e-22
• PF13460: NAD_binding_10
  • amino acids 8 to 171 (164 residues), 45.9 bits, E=2.2e-15
• PF02719: Polysacc_synt_2
  • amino acids 61 to 168 (108 residues), 27.5 bits, E=6.1e-10
• PF07993: NAD_binding_4
  • amino acids 64 to 176 (113 residues), 50 bits, E=8e-17

Best Hits

KEGG orthology group: K01784, UDP-glucose 4-epimerase [EC: 5.1.3.2] (inferred from 83% identity to bph:Bphy_2291)

Predicted SEED Role

"UDP-glucose 4-epimerase (EC 5.1.3.2)" in subsystem Lacto-N-Biose I and Galacto-N-Biose Metabolic Pathway or Lactose and Galactose Uptake and Utilization or N-linked Glycosylation in Bacteria or Rhamnose containing glycans or linker unit-arabinogalactan synthesis (EC 5.1.3.2)

MetaCyc Pathways

• colanic acid building blocks biosynthesis (11/11 steps found)
• UDP-α-D-galactose biosynthesis (1/1 steps found)
• UDP-N-acetyl-D-galactosamine biosynthesis I (1/1 steps found)
• UDP-N-acetyl-D-galactosamine biosynthesis II (5/7 steps found)
• superpathway of UDP-glucose-derived O-antigen building blocks biosynthesis (4/6 steps found)
• UDP-α-D-galactofuranose biosynthesis (1/2 steps found)
• D-galactose degradation I (Leloir pathway) (3/5 steps found)
• D-galactose detoxification (1/3 steps found)
• stachyose degradation (2/7 steps found)
• UDP-sugars interconversion (3/9 steps found)
• teichuronic acid biosynthesis (B. subtilis 168) (2/9 steps found)
• superpathway of mycolyl-arabinogalactan-peptidoglycan complex biosynthesis (12/33 steps found)
• mycolyl-arabinogalactan-peptidoglycan complex biosynthesis (1/18 steps found)

KEGG Metabolic Maps

• Galactose metabolism
• Nucleotide sugars metabolism

Isozymes

Compare fitness of predicted isozymes for: 5.1.3.2

Use Curated BLAST to search for 5.1.3.2

Protein Sequence (318 amino acids)

>H281DRAFT_04849 UDP-glucose 4-epimerase (Paraburkholderia bryophila 376MFSha3.1)
MSHVVVSGANGFVGRALCRALLGAGHCVTGLVRRSGNCVDGVTEWVDASTDYHGIAHNWP
ANMKADCVVHLAARVHVMHDTAADPETAFRATNVDGTLRLAATARRHGVPRFVFVSSIKA
VAEQSRGQSLCENDSPRPEDAYGRSKRAAEDALIRMGDDTGLEVVIVRPPLVYGPHVRAN
FLRLMDAVWRGVPLPLGGADARRSMVYVGNLADALVHCATDARAARQCFHVADSDAPTVA
ELVRSLGRHLGKPVRLLPVPAAWLRMAARLTGQSSRVDRLLGSLQVDTSHIRDVLGWHPP
FSTDEGLAATADWYRSTH