Protein Info for H281DRAFT_04772 in Paraburkholderia bryophila 376MFSha3.1
Annotation: mannose-6-phosphate isomerase, type 2
These analyses and tools can help you predict a protein's function, but be skeptical. For enzymes, over 10% of annotations from KEGG or SEED are probably incorrect. For other types of proteins, the error rates may be much higher. MetaCyc and Swiss-Prot have low error rates, but the best hits in these databases are often quite distant, so this protein's function may not be the same. TIGRFam has low error rates. Finally, many experimentally-characterized proteins are not in any of these databases. To find relevant papers, use PaperBLAST.
Protein Families and Features
Best Hits
KEGG orthology group: None (inferred from 91% identity to bgf:BC1003_0546)Predicted SEED Role
"Mannose-1-phosphate guanylyltransferase (GDP) (EC 2.7.7.22); Mannose-6-phosphate isomerase (EC 5.3.1.8)" (EC 2.7.7.22, EC 5.3.1.8)
MetaCyc Pathways
- colanic acid building blocks biosynthesis (11/11 steps found)
- GDP-mannose biosynthesis (4/4 steps found)
- β-1,4-D-mannosyl-N-acetyl-D-glucosamine degradation (2/3 steps found)
- D-mannose degradation I (1/2 steps found)
- D-mannose degradation II (1/2 steps found)
- mannitol degradation II (2/4 steps found)
- superpathway of GDP-mannose-derived O-antigen building blocks biosynthesis (9/14 steps found)
- mannitol biosynthesis (1/3 steps found)
- 1,5-anhydrofructose degradation (2/5 steps found)
- β-(1,4)-mannan degradation (2/7 steps found)
KEGG Metabolic Maps
Isozymes
Compare fitness of predicted isozymes for: 2.7.7.22, 5.3.1.8
Use Curated BLAST to search for 2.7.7.22 or 5.3.1.8
Sequence Analysis Tools
PaperBLAST (search for papers about homologs of this protein)
Search CDD (the Conserved Domains Database, which includes COG and superfam)
Predict protein localization: PSORTb (Gram-negative bacteria)
Predict transmembrane helices and signal peptides: Phobius
Check the current SEED with FIGfam search
Find homologs in fast.genomics or the ENIGMA genome browser
See A0A2Z5M8S7 at UniProt or InterPro
Protein Sequence (515 amino acids)
>H281DRAFT_04772 mannose-6-phosphate isomerase, type 2 (Paraburkholderia bryophila 376MFSha3.1) MLTQGTENGASSNASGEATGARCTRIVPVILAGGSGTRLWPVSRENYPKQLIDVVGSDSL LQATARRMNGFPSNWQVDASPIIVCGEEHRFVIAEQLHENGVEARLIVEPARRDTAPALT LAASLACADGKDGILVVMPADHSIADLGALQAALESAALYAERGAIATLGVPPTRPDTGF GYIRIGAALPDGGHAIDGFVEKPAEELAAKYVAAGTYWWNSGIFIVRASVWLDTLARLQP EMHAACERAFRDGRSEGAYFRPLVDAFLSAPADSIDYAVMERLTDTPDANATEPAHADGA SPAGVVVRLEAGWSDLGSWDAVWAAMEKDANGNAGRGRVTFEGAVSSYAHSEGRLVACVG TTNVVVVETADAVLVVDRSHVQDVKGLVSRIKAQHAPEADAHRKVHRPWGFYDSIDHGER FQVKRIVVSPGAQLSLQLHHHRAEHWVVVRGTALVTRGEEQFLLSENESTYIPLGTRHRL ENPGKVPLEIIEIQSGTYLGEDDIVRFNDNYGRCS