Protein Info for H281DRAFT_04753 in Paraburkholderia bryophila 376MFSha3.1

Annotation: xanthine dehydrogenase, molybdenum binding subunit apoprotein

These analyses and tools can help you predict a protein's function, but be skeptical. For enzymes, over 10% of annotations from KEGG or SEED are probably incorrect. For other types of proteins, the error rates may be much higher. MetaCyc and Swiss-Prot have low error rates, but the best hits in these databases are often quite distant, so this protein's function may not be the same. TIGRFam has low error rates. Finally, many experimentally-characterized proteins are not in any of these databases. To find relevant papers, use PaperBLAST.

Protein Families and Features

• TIGR02965: xanthine dehydrogenase, molybdopterin binding subunit
  • amino acids 21 to 780 (760 residues), 1327.3 bits, E=0
• PF01315: Ald_Xan_dh_C
  • amino acids 35 to 143 (109 residues), 101.2 bits, E=6.2e-33
• PF02738: MoCoBD_1
  • amino acids 160 to 395 (236 residues), 257.8 bits, E=1.2e-80
• PF20256: MoCoBD_2
  • amino acids 422 to 709 (288 residues), 323 bits, E=2.9e-100

Best Hits

KEGG orthology group: K13482, xanthine dehydrogenase large subunit [EC: 1.17.1.4] (inferred from 97% identity to bug:BC1001_0500)

Predicted SEED Role

"Xanthine dehydrogenase, molybdenum binding subunit (EC 1.17.1.4)" in subsystem Purine Utilization (EC 1.17.1.4)

MetaCyc Pathways

• purine nucleotides degradation I (plants) (10/12 steps found)
• adenosine nucleotides degradation I (7/8 steps found)
• guanosine nucleotides degradation II (4/4 steps found)
• superpathway of purines degradation in plants (14/18 steps found)
• superpathway of guanosine nucleotides degradation (plants) (5/6 steps found)
• adenosine nucleotides degradation II (4/5 steps found)
• guanosine nucleotides degradation I (3/4 steps found)
• guanosine nucleotides degradation III (3/4 steps found)
• inosine 5'-phosphate degradation (3/4 steps found)
• purine nucleotides degradation II (aerobic) (8/11 steps found)
• ureide biosynthesis (5/7 steps found)
• purine nucleobases degradation II (anaerobic) (16/24 steps found)
• caffeine degradation III (bacteria, via demethylation) (1/7 steps found)
• theophylline degradation (1/9 steps found)
• caffeine degradation IV (bacteria, via demethylation and oxidation) (1/10 steps found)

KEGG Metabolic Maps

• Purine metabolism

Isozymes

Compare fitness of predicted isozymes for: 1.17.1.4

Use Curated BLAST to search for 1.17.1.4

Sequence Analysis Tools

See A0A2Z5MAA4 at UniProt or InterPro

Protein Sequence (787 amino acids)

>H281DRAFT_04753 xanthine dehydrogenase, molybdenum binding subunit apoprotein (Paraburkholderia bryophila 376MFSha3.1)
MNQHAEPFLKDAQALDDFTQVHVSRPHESAHLHVSGRATYTDDIPTVAGTLHAALGLSSK
AHAKIVSVSLDKVRATPGVVAIFTADDIPGANDVAPIVHGDDPILADGIVQYVGQPVFIV
VATSHETARLAARRAEIVYEELPAILTAQQARAANQHVLPPMKLARGEAGTKIARASHRE
AGEMLLGGQEQFYLEGQISYAVPKDDDGMHVYCSTQHPTEMQHLVAHALGIASHNVLIEC
RRMGGGFGGKESQSGLFACCAALAAWKLLCPVKLRPDRDDDMMVTGKRHDFHYTYEVGYD
DKGVIEGVAVDMTSRCGFSADLSGPVMTRALCHFDNAYWLSDVTIDGFCGKTNTQSNTAF
RGFGGPQGAFAIEYIMDNVARSIGEDSLDVRRRNLYGKTERNQTPYGQIVEDNVIHELID
ELEATSEYRARRAAINEFNANNEVLKKGLALTPVKFGIAFNVTHFNQAGALVHIYTDGSV
LVNHGGTEMGQGLNTKVAQVVAHELGVGFNRIRVTATDTSKVANTSATAASTGSDLNGKA
AQDAARQLRERLAAFAAERFGGGQVNASDVRFAHDRVIVGEAVVPFEEVVAKAYLARIQL
WSDGFYATPKLYWDQAKLQGRPFYYYSYGAAVSEVVIDTLTGEMRVLRADALHDVGASLN
PALDIGQVEGAFIQGMGWLTTEELWWNAGGKLMTHAPSTYKIPTVNDTPPVFNVRLFKNR
NAEDSIHRSKATGEPPLLLPFSVFFAIRDAVSAVGGHRVNPPLNAPATSEEILRAIGAVR
AATSAAR