Protein Info for H281DRAFT_04724 in Paraburkholderia bryophila 376MFSha3.1

Annotation: 3-hydroxy acid dehydrogenase / malonic semialdehyde reductase

These analyses and tools can help you predict a protein's function, but be skeptical. For enzymes, over 10% of annotations from KEGG or SEED are probably incorrect. For other types of proteins, the error rates may be much higher. MetaCyc and Swiss-Prot have low error rates, but the best hits in these databases are often quite distant, so this protein's function may not be the same. TIGRFam has low error rates. Finally, many experimentally-characterized proteins are not in any of these databases. To find relevant papers, use PaperBLAST.

Protein Families and Features

• PF00106: adh_short
  • amino acids 2 to 187 (186 residues), 170 bits, E=8.7e-54
• PF08659: KR
  • amino acids 3 to 163 (161 residues), 43.7 bits, E=5.8e-15
• PF01370: Epimerase
  • amino acids 3 to 134 (132 residues), 23.4 bits, E=7.4e-09
• PF13561: adh_short_C2
  • amino acids 7 to 221 (215 residues), 119.3 bits, E=4.2e-38

Best Hits

Swiss-Prot: 71% identical to YDFG_SALTI: NADP-dependent 3-hydroxy acid dehydrogenase YdfG (ydfG) from Salmonella typhi

KEGG orthology group: None (inferred from 95% identity to bge:BC1002_0529)

MetaCyc: 68% identical to 3-hydroxy acid dehydrogenase YdfG (Escherichia coli K-12 substr. MG1655)
RXN-16000 [EC: 1.1.1.381]; RXN-8974 [EC: 1.1.1.381, 1.1.1.298]; Serine 3-dehydrogenase. [EC: 1.1.1.381, 1.1.1.298, 1.1.1.276]

Predicted SEED Role

"3-hydroxypropionate dehydrogenase (EC 1.1.1.298)" (EC 1.1.1.298)

MetaCyc Pathways

• superpathway of L-threonine metabolism (15/18 steps found)
• L-threonine degradation III (to methylglyoxal) (2/3 steps found)
• β-alanine degradation III (1/2 steps found)
• uracil degradation III (3/5 steps found)
• aminopropanol phosphate biosynthesis II (2/4 steps found)
• 3-hydroxypropanoate cycle (8/13 steps found)
• superpathway of the 3-hydroxypropanoate cycle (10/18 steps found)
• glyoxylate assimilation (6/13 steps found)
• 3-hydroxypropanoate/4-hydroxybutanate cycle (9/18 steps found)

Isozymes

No predicted isozymes

Use Curated BLAST to search for 1.1.1.276 or 1.1.1.298 or 1.1.1.381

Sequence Analysis Tools

See A0A2Z5M9H7 at UniProt or InterPro

Protein Sequence (248 amino acids)

>H281DRAFT_04724 3-hydroxy acid dehydrogenase / malonic semialdehyde reductase (Paraburkholderia bryophila 376MFSha3.1)
MIVFVTGASAGFGAAIARAFVKGGHRVVATARRKDRLDALAAELGDALLPYELDVRDRAA
VEAVPAALPADFAAIDVLVNNAGLALGVEPAQKASLDEWQTMIETNCTGLVQVTHALLPG
MVERNRGHIFNLGSVAGRWPYAGGNVYGATKAFVRQFSLNLRADLAGTALRVTDIEPGLC
GGTEFSNVRFRGDDEKADKVYENVQPLTAEDIADSIYWIATRPAHVNINTIELMPVAQSF
AGLSVHRG