Protein Info for H281DRAFT_04694 in Paraburkholderia bryophila 376MFSha3.1

Annotation: heat-inducible transcription repressor HrcA

These analyses and tools can help you predict a protein's function, but be skeptical. For enzymes, over 10% of annotations from KEGG or SEED are probably incorrect. For other types of proteins, the error rates may be much higher. MetaCyc and Swiss-Prot have low error rates, but the best hits in these databases are often quite distant, so this protein's function may not be the same. TIGRFam has low error rates. Finally, many experimentally-characterized proteins are not in any of these databases. To find relevant papers, use PaperBLAST.

Protein Families and Features

1 50 100 150 200 250 300 339 PF03444: HrcA_DNA-bdg" amino acids 2 to 73 (72 residues), 26.4 bits, see alignment E=4.3e-10 TIGR00331: heat-inducible transcription repressor HrcA" amino acids 3 to 333 (331 residues), 312.9 bits, see alignment E=1.8e-97 PF01628: HrcA" amino acids 105 to 322 (218 residues), 221.2 bits, see alignment E=1.7e-69

Best Hits

Swiss-Prot: 98% identical to HRCA_PARPJ: Heat-inducible transcription repressor HrcA (hrcA) from Paraburkholderia phytofirmans (strain DSM 17436 / LMG 22146 / PsJN)

KEGG orthology group: K03705, heat-inducible transcriptional repressor (inferred from 99% identity to bug:BC1001_0446)

Predicted SEED Role

"Heat-inducible transcription repressor HrcA" in subsystem Heat shock dnaK gene cluster extended

Sequence Analysis Tools

PaperBLAST (search for papers about homologs of this protein)

Search CDD (the Conserved Domains Database, which includes COG and superfam)

Search structures

Predict protein localization: PSORTb (Gram-negative bacteria)

Predict transmembrane helices and signal peptides: Phobius

Check the current SEED with FIGfam search

Find homologs in fast.genomics or the ENIGMA genome browser

See A0A2Z5M8L1 at UniProt or InterPro

Protein Sequence (339 amino acids)

>H281DRAFT_04694 heat-inducible transcription repressor HrcA (Paraburkholderia bryophila 376MFSha3.1)
MLDPRAQTLLKTLIERYIAEGQPVGSRTLSRYSGLELSPATIRNVMSDLEDLGLVISPHT
SAGRIPTPRGYRLFVDTMLTVESAADEEAVTRTVKTTLQAGEPQKIVAAAASVLSNLSQF
AGVVLTPRRSHVFKQIEFMRLSDKRILLIIVTPEGDVQNRMMATQRDFTPSELVEASNYI
NAHFAGLSFDEVRRRLREEIDQLRGDMTTLMHAAVTASTDESDTGETVLISGERNLLEVA
DLSSDMARLRKLFDVFDQKTSLLQLLDVSSHAAGVQIFIGGESNLVPIEEMSVVTAPYEV
NGKIVGTLGVIGPTRMAYNRVIPIVDITARLLSLTLSQQ