Protein Info for H281DRAFT_04686 in Paraburkholderia bryophila 376MFSha3.1

Annotation: nitric oxide dioxygenase

These analyses and tools can help you predict a protein's function, but be skeptical. For enzymes, over 10% of annotations from KEGG or SEED are probably incorrect. For other types of proteins, the error rates may be much higher. MetaCyc and Swiss-Prot have low error rates, but the best hits in these databases are often quite distant, so this protein's function may not be the same. TIGRFam has low error rates. Finally, many experimentally-characterized proteins are not in any of these databases. To find relevant papers, use PaperBLAST.

Protein Families and Features

1 50 100 150 200 250 300 350 401 PF00042: Globin" amino acids 29 to 133 (105 residues), 55 bits, see alignment E=1.8e-18 PF00175: NAD_binding_1" amino acids 269 to 377 (109 residues), 53.7 bits, see alignment E=4.6e-18

Best Hits

Swiss-Prot: 57% identical to HMP_BORPA: Flavohemoprotein (hmp) from Bordetella parapertussis (strain 12822 / ATCC BAA-587 / NCTC 13253)

KEGG orthology group: K05916, nitric oxide dioxygenase [EC: 1.14.12.17] (inferred from 92% identity to bug:BC1001_0436)

Predicted SEED Role

"Flavohemoprotein (Hemoglobin-like protein) (Flavohemoglobin) (Nitric oxide dioxygenase) (EC 1.14.12.17)" in subsystem Bacterial hemoglobins or Flavohaemoglobin or Glutaredoxins (EC 1.14.12.17)

Isozymes

Compare fitness of predicted isozymes for: 1.14.12.17

Use Curated BLAST to search for 1.14.12.17

Sequence Analysis Tools

PaperBLAST (search for papers about homologs of this protein)

Search CDD (the Conserved Domains Database, which includes COG and superfam)

Search structures

Predict protein localization: PSORTb (Gram-negative bacteria)

Predict transmembrane helices and signal peptides: Phobius

Check the current SEED with FIGfam search

Find homologs in fast.genomics or the ENIGMA genome browser

Find the best match in UniProt

Protein Sequence (401 amino acids)

>H281DRAFT_04686 nitric oxide dioxygenase (Paraburkholderia bryophila 376MFSha3.1)
MTALTAEQIARVKATVPVLAEHGTTITKHFYKRMFARHPELKNLFNQTHQQSGNQPETLA
RAVYAYAANIDNLGALGPTVSRIANKHASLNIRPEHYPIVGRHLLGAIVDVLGDAVDQPT
LDAWQVAYGQLANIFVGTEAKLYEGAAWSGFRPFKVARKQVESDEITSFYLTPADGSAAC
DFEPGQYVSVKRFVDKLGVDQPRQYSLSDAPHGKWLRISVKREDGREDIAPGHVSNLLHA
DVEEGTVVHVSAPMGDFTLDRKKTTPVVLMSGGVGVTPMTSMLSTILADGSERSVTFVHA
CRNGRVHAFRQWLNETVASHSNVKRVVFYEAVGEGDRRGVDYDFDGRLDVAGIAGQVIVP
DADYYICGPVPFMRAQCDALAALGVDPARIHTEVFGSGVVE