Protein Info for H281DRAFT_04638 in Paraburkholderia bryophila 376MFSha3.1

Annotation: periplasmic chaperone for outer membrane proteins SurA

These analyses and tools can help you predict a protein's function, but be skeptical. For enzymes, over 10% of annotations from KEGG or SEED are probably incorrect. For other types of proteins, the error rates may be much higher. MetaCyc and Swiss-Prot have low error rates, but the best hits in these databases are often quite distant, so this protein's function may not be the same. TIGRFam has low error rates. Finally, many experimentally-characterized proteins are not in any of these databases. To find relevant papers, use PaperBLAST.

Protein Families and Features

1 50 100 150 200 250 300 350 400 469 signal peptide" amino acids 1 to 46 (46 residues), see Phobius details PF13624: SurA_N_3" amino acids 32 to 173 (142 residues), 58.2 bits, see alignment E=2.8e-19 PF13623: SurA_N_2" amino acids 47 to 134 (88 residues), 42.4 bits, see alignment E=2e-14 PF09312: SurA_N" amino acids 57 to 174 (118 residues), 120 bits, see alignment E=2e-38 PF13616: Rotamase_3" amino acids 205 to 307 (103 residues), 55.8 bits, see alignment E=2e-18 amino acids 321 to 419 (99 residues), 92.8 bits, see alignment E=6.5e-30 PF00639: Rotamase" amino acids 211 to 305 (95 residues), 71 bits, see alignment E=4.1e-23 amino acids 327 to 416 (90 residues), 85.5 bits, see alignment E=1.3e-27 PF13145: Rotamase_2" amino acids 227 to 311 (85 residues), 41.2 bits, see alignment E=8.1e-14 amino acids 347 to 422 (76 residues), 28.6 bits, see alignment E=6.7e-10

Best Hits

Swiss-Prot: 92% identical to SURA_PARXL: Chaperone SurA (surA) from Paraburkholderia xenovorans (strain LB400)

KEGG orthology group: K03771, peptidyl-prolyl cis-trans isomerase SurA [EC: 5.2.1.8] (inferred from 95% identity to bgf:BC1003_0400)

Predicted SEED Role

"Survival protein SurA precursor (Peptidyl-prolyl cis-trans isomerase SurA) (EC 5.2.1.8)" in subsystem Peptidyl-prolyl cis-trans isomerase (EC 5.2.1.8)

Isozymes

Compare fitness of predicted isozymes for: 5.2.1.8

Use Curated BLAST to search for 5.2.1.8

Sequence Analysis Tools

PaperBLAST (search for papers about homologs of this protein)

Search CDD (the Conserved Domains Database, which includes COG and superfam)

Search structures

Predict protein localization: PSORTb (Gram-negative bacteria)

Predict transmembrane helices and signal peptides: Phobius

Check the current SEED with FIGfam search

Find homologs in fast.genomics or the ENIGMA genome browser

See A0A2Z5M7R6 at UniProt or InterPro

Protein Sequence (469 amino acids)

>H281DRAFT_04638 periplasmic chaperone for outer membrane proteins SurA (Paraburkholderia bryophila 376MFSha3.1)
MRKDGPGVPDIIGVSVAIMKKLRLATLAAGLAAAASFLSVAPVQAQALGGNRGGQTVDTI
AAVVNNGVITRRELEERVGLITRRLSQQNAPIPPADQLRQQVLNQMVLERIQLQKAKEDG
INIDDAAVQKTLERLAQANNLSLDVYRSRIEAQGVPWATFTSDARTELTLSRLREKEVDS
KVTVSDAEVANYIASQRGPNAGATSDLHMQHILLKAPLNAPQTDIEAAQKKAEALLAEAK
GGANFEKLAKSNSQAPDASKGGDMGFAAPSKLPPEFVKAASALRPGQVNPEVIRTNDGFE
VVRLVDRRSGQGTSSDAPKLVQTHVRHILLRVGDGMSEPQARQKLLEIKKEIAAGGDFAK
FAHTYSQDGSSSQGGDLGWISPGETVPEFERAMNTLQDGQISDPVRSEYGYHLIQVLERR
ESEGSIAQQMDLARQAIGQRKAEQAYADWLRELRDTAYVEVKPDLSRVQ