Protein Info for H281DRAFT_04622 in Paraburkholderia bryophila 376MFSha3.1

Annotation: putative cardiolipin synthase

These analyses and tools can help you predict a protein's function, but be skeptical. For enzymes, over 10% of annotations from KEGG or SEED are probably incorrect. For other types of proteins, the error rates may be much higher. MetaCyc and Swiss-Prot have low error rates, but the best hits in these databases are often quite distant, so this protein's function may not be the same. TIGRFam has low error rates. Finally, many experimentally-characterized proteins are not in any of these databases. To find relevant papers, use PaperBLAST.

Protein Families and Features

• PF13091: PLDc_2
  • amino acids 46 to 147 (102 residues), 47.2 bits, E=1.9e-16
  • amino acids 251 to 370 (120 residues), 89.8 bits, E=1.3e-29

Best Hits

KEGG orthology group: K06132, putative cardiolipin synthase [EC: 2.7.8.-] (inferred from 92% identity to bgf:BC1003_0384)

Predicted SEED Role

"Cardiolipin synthetase (EC 2.7.8.-)" in subsystem Glycerolipid and Glycerophospholipid Metabolism in Bacteria (EC 2.7.8.-)

MetaCyc Pathways

• cardiolipin biosynthesis II (3/3 steps found)
• cardiolipin and phosphatidylethanolamine biosynthesis (Xanthomonas) (3/4 steps found)
• superpathway of cardiolipin biosynthesis (bacteria) (9/13 steps found)

KEGG Metabolic Maps

• Aminophosphonate metabolism
• Glycerophospholipid metabolism
• High-mannose type N-glycan biosynthesis
• Nucleotide sugars metabolism
• Sphingolipid metabolism

Isozymes

Compare fitness of predicted isozymes for: 2.7.8.-

Use Curated BLAST to search for 2.7.8.-

Sequence Analysis Tools

See A0A2Z5M973 at UniProt or InterPro

Protein Sequence (419 amino acids)

>H281DRAFT_04622 putative cardiolipin synthase (Paraburkholderia bryophila 376MFSha3.1)
MSVGGARRFARLRQSLLGRRYWQRYRFTSGNDVKLLRSGGEYFSALIERVDAAERDVVLE
TYIFCNDEAGQSVGAALLRAAARGVRVRVITDGIGTARLSMFDEWASAGIEHRIYNPHIF
GRFGFSRTHRKLAVIDDQFGYCGGINIVDDYENDGERLPYRRWDFAVELHGPVVNDIREA
FEVQWRRIRVGHRPLDSLEPDLTPKTASSLGNLRRRRRRRNEELWAGGEPCVAFVARDNL
INRRAIEKAYLTAIGQARHEVLLANPYFMPGRKLRRALVYAARRGVVVKLIIGRKEFKAL
DYAVPFLYRALLRAGVQIAEYEKTLLHGKVAVVDSNWATVGSSNLDALSLMLNNEANVVL
VNDPSIDALREAILVAFKDSRRIDEAHYDARPAGERLLNWLAYTTYRAVMKVLTVGGYD