Protein Info for H281DRAFT_04469 in Paraburkholderia bryophila 376MFSha3.1

Annotation: ATP-dependent DNA helicase UvrD

These analyses and tools can help you predict a protein's function, but be skeptical. For enzymes, over 10% of annotations from KEGG or SEED are probably incorrect. For other types of proteins, the error rates may be much higher. MetaCyc and Swiss-Prot have low error rates, but the best hits in these databases are often quite distant, so this protein's function may not be the same. TIGRFam has low error rates. Finally, many experimentally-characterized proteins are not in any of these databases. To find relevant papers, use PaperBLAST.

Protein Families and Features

1 50 100 150 200 250 300 350 400 450 500 550 600 650 700 750 787 PF00580: UvrD-helicase" amino acids 8 to 268 (261 residues), 301.2 bits, see alignment E=3.1e-93 PF13245: AAA_19" amino acids 12 to 254 (243 residues), 84.2 bits, see alignment E=3.4e-27 PF13361: UvrD_C" amino acids 274 to 650 (377 residues), 262.3 bits, see alignment E=3.1e-81 PF13538: UvrD_C_2" amino acids 590 to 646 (57 residues), 38.5 bits, see alignment 2.9e-13 PF21196: PcrA_UvrD_tudor" amino acids 738 to 781 (44 residues), 27.4 bits, see alignment 8.9e-10

Best Hits

KEGG orthology group: K03657, DNA helicase II / ATP-dependent DNA helicase PcrA [EC: 3.6.4.12] (inferred from 99% identity to bug:BC1001_2445)

Predicted SEED Role

"ATP-dependent DNA helicase UvrD/PcrA" in subsystem DNA repair, bacterial UvrD and related helicases

Isozymes

Compare fitness of predicted isozymes for: 3.6.4.12

Use Curated BLAST to search for 3.6.4.12

Sequence Analysis Tools

PaperBLAST (search for papers about homologs of this protein)

Search CDD (the Conserved Domains Database, which includes COG and superfam)

Search structures

Predict protein localization: PSORTb (Gram-negative bacteria)

Predict transmembrane helices and signal peptides: Phobius

Check the current SEED with FIGfam search

Find homologs in fast.genomics or the ENIGMA genome browser

See A0A2Z5MCW8 at UniProt or InterPro

Protein Sequence (787 amino acids)

>H281DRAFT_04469 ATP-dependent DNA helicase UvrD (Paraburkholderia bryophila 376MFSha3.1)
MPDLLANLNPEQHAAVTLPNEPALILAGAGSGKTRVLITRIAWLIQHGLASPATILAVTF
TNKAAREMMSRLSALLPIDTRGMWIGTFHGLCNRMLRAHHRDAGLPATFQILDTADQLSA
IKRLMKGLNIDDEKYPAKNLQYFINNAKEQGLRPKDVDATDNFNRKFVELYEAYDQQCQR
EGVVDFPELLLRCYELLAHNPPLRAHYQARFKHILVDEFQDTNKLQYAWLKLLAGQTNSI
FAVGDDDQSIYAFRGANVGNMRDFEHEFNVRHLIKLEQNYRSHGHILDAANQLIANNSRR
LGKNLRTDAGHGEPVRVYESATDSQEAGWIVEEIKALISTGTSRSEIAILYRSNAQSRTI
EHTLVNAGIAYRVYGGLRFFERQEVKHALAYLRLIDNPNDDTAFARVVNFPTRGIGARSI
EQLADAARLYNCSMAAAIPYVAGKAGSSLASFANLIGKMRAETQQMSLPETVEYVVRASG
LADFYQNEREGQDRLENLQELVNAAAAFVSEEGYGMDTPARSIPLRPGATAAPELAVATD
DPNTVVLDAPGIADPAQNPDTMTPLAGFLSHASLEAGDNQAQAGQEAVQLMTVHAAKGLE
FTAVFITGLEEGLFPHENSAMESDGLEEERRLMYVAITRAKERLYLSFAQSRMLHGQTRY
NIRSRFFDELPQETLKWLTPKVEAGARWGGRSDNAGYGRDWFARPDRQQGYGGGASTAAA
PLPAFANEQRAAEAGFRVGQQVFHTKFGEGTITALEGGGADAKAQVKFKRHGEKWLALAV
AKLQAVE