Protein Info for H281DRAFT_04464 in Paraburkholderia bryophila 376MFSha3.1

Annotation: myo-inositol 2-dehydrogenase

These analyses and tools can help you predict a protein's function, but be skeptical. For enzymes, over 10% of annotations from KEGG or SEED are probably incorrect. For other types of proteins, the error rates may be much higher. MetaCyc and Swiss-Prot have low error rates, but the best hits in these databases are often quite distant, so this protein's function may not be the same. TIGRFam has low error rates. Finally, many experimentally-characterized proteins are not in any of these databases. To find relevant papers, use PaperBLAST.

Protein Families and Features

1 50 100 150 200 250 300 339 TIGR04380: inositol 2-dehydrogenase" amino acids 8 to 333 (326 residues), 415.8 bits, see alignment E=5.1e-129 PF01408: GFO_IDH_MocA" amino acids 9 to 125 (117 residues), 79.7 bits, see alignment E=2.9e-26 PF02894: GFO_IDH_MocA_C" amino acids 137 to 334 (198 residues), 93.8 bits, see alignment E=1.4e-30

Best Hits

Swiss-Prot: 44% identical to YRBE_BACSU: Uncharacterized oxidoreductase YrbE (yrbE) from Bacillus subtilis (strain 168)

KEGG orthology group: K00010, myo-inositol 2-dehydrogenase [EC: 1.1.1.18] (inferred from 94% identity to bpy:Bphyt_2804)

Predicted SEED Role

"Myo-inositol 2-dehydrogenase 1 (EC 1.1.1.18)" in subsystem Inositol catabolism (EC 1.1.1.18)

MetaCyc Pathways

KEGG Metabolic Maps

Isozymes

Compare fitness of predicted isozymes for: 1.1.1.18

Use Curated BLAST to search for 1.1.1.18

Sequence Analysis Tools

PaperBLAST (search for papers about homologs of this protein)

Search CDD (the Conserved Domains Database, which includes COG and superfam)

Search structures

Predict protein localization: PSORTb (Gram-negative bacteria)

Predict transmembrane helices and signal peptides: Phobius

Check the current SEED with FIGfam search

Find homologs in fast.genomics or the ENIGMA genome browser

See A0A2Z5MD37 at UniProt or InterPro

Protein Sequence (339 amino acids)

>H281DRAFT_04464 myo-inositol 2-dehydrogenase (Paraburkholderia bryophila 376MFSha3.1)
MTDAAKPIDVAVFGAGRIGKIHAANLARQPGVRLKYVVDVNSEAAAALAAAHGAKVADID
GAMGDASVGATVICSSTDTHADLIMKSAAQKKHVFCEKPVDLTLERARACADAVERAGVV
CMIGFQRRFDPTFSALKARLDAGEIGTPEMLVVTSRDPGAPPVDYIRHSGGIFKDMLIHD
FDIFRWILGDEADTLHATGSCLSDPAIAEAGDIDSTAVTIRTKRGRLCQINTARRAAYGY
DQRFEVLGSAGMLQAGNVRPTEVTAYSRTQVSSDVPEAFFLERYRAAYALEIAHFFEAVT
QGKPVRTTVADGLKALELAEAATRSWREGRAVKLGEAAQ