Protein Info for H281DRAFT_04442 in Paraburkholderia bryophila 376MFSha3.1

Annotation: gamma-glutamyltransferase 1 (EC:2.3.2.2). Threonine peptidase. MEROPS family T03

These analyses and tools can help you predict a protein's function, but be skeptical. For enzymes, over 10% of annotations from KEGG or SEED are probably incorrect. For other types of proteins, the error rates may be much higher. MetaCyc and Swiss-Prot have low error rates, but the best hits in these databases are often quite distant, so this protein's function may not be the same. TIGRFam has low error rates. Finally, many experimentally-characterized proteins are not in any of these databases. To find relevant papers, use PaperBLAST.

Protein Families and Features

1 50 100 150 200 250 300 350 400 450 500 550 599 signal peptide" amino acids 1 to 20 (20 residues), see Phobius details amino acids 43 to 43 (1 residues), see Phobius details transmembrane" amino acids 21 to 42 (22 residues), see Phobius details TIGR00066: gamma-glutamyltransferase" amino acids 57 to 590 (534 residues), 461.7 bits, see alignment E=1.4e-142 PF01019: G_glu_transpept" amino acids 70 to 592 (523 residues), 485 bits, see alignment E=1.5e-149

Best Hits

KEGG orthology group: K00681, gamma-glutamyltranspeptidase [EC: 2.3.2.2] (inferred from 81% identity to bpy:Bphyt_2827)

Predicted SEED Role

"Gamma-glutamyltranspeptidase (EC 2.3.2.2)" in subsystem Glutathione: Biosynthesis and gamma-glutamyl cycle or Utilization of glutathione as a sulphur source (EC 2.3.2.2)

MetaCyc Pathways

KEGG Metabolic Maps

Isozymes

Compare fitness of predicted isozymes for: 2.3.2.2

Use Curated BLAST to search for 2.3.2.2

Sequence Analysis Tools

PaperBLAST (search for papers about homologs of this protein)

Search CDD (the Conserved Domains Database, which includes COG and superfam)

Search structures

Predict protein localization: PSORTb (Gram-negative bacteria)

Predict transmembrane helices and signal peptides: Phobius

Check the current SEED with FIGfam search

Find homologs in fast.genomics or the ENIGMA genome browser

Find the best match in UniProt

Protein Sequence (599 amino acids)

>H281DRAFT_04442 gamma-glutamyltransferase 1 (EC:2.3.2.2). Threonine peptidase. MEROPS family T03 (Paraburkholderia bryophila 376MFSha3.1)
MPILTHDAPCAPFAFTSFARLIAAATLSATFAACIVAPAAVFAKTPQPKAVFDASAVAAP
DRYSADAAQQIFAAGGNAVDAAVAIAFTLAVTRPDAGNLGGGGFMTLFVDGKPYFLDYRE
RAPQQATRDMYLDDKGNVVLGMSSIGHRAVAVPGSVDGMWQAQQRFGKLKWKQVLAPAIR
YATEGFQVDPRLQQQRDAAAKNFAGRTNFDAYFSGMKAGATYRQPELAQTLTRIASDGGR
EFYEGRTADLLAQQMYGHGFVTKGDLLQYKAVWRQPLTANWNGYQVLTAPPPSSGGVGLI
QMLKMKADLKPAFDGLELNSAPYIHLVAQIEDRVFADRQQYLGDPDSYKLPVDKLLDDAY
LSQRASEVSADEVPGATPVKPGLGDAVPEKAQTTHFSVVDKWGNAVSNTTTLDGEFGSGV
VVDGAGFLLNDAMDDFVTKAGAAGPSGSTSATAATGATGATAATGAELNTVVAGRRPLSS
MTPTILLKDNKVSLVIGTPGGSRILTSIFQVMTDLYDFNMPPGDALAAMRFHHQLLPPKT
IYFEPYHPITGELATALQDLGYTLEGQSFNGDVQMIRIDGTTPEPAADPRGMGTGRVIR