Protein Info for H281DRAFT_04431 in Paraburkholderia bryophila 376MFSha3.1

Annotation: Membrane-bound metallopeptidase

These analyses and tools can help you predict a protein's function, but be skeptical. For enzymes, over 10% of annotations from KEGG or SEED are probably incorrect. For other types of proteins, the error rates may be much higher. MetaCyc and Swiss-Prot have low error rates, but the best hits in these databases are often quite distant, so this protein's function may not be the same. TIGRFam has low error rates. Finally, many experimentally-characterized proteins are not in any of these databases. To find relevant papers, use PaperBLAST.

Protein Families and Features

1 50 100 150 200 238 signal peptide" amino acids 1 to 26 (26 residues), see Phobius details PF01476: LysM" amino acids 33 to 75 (43 residues), 54.5 bits, see alignment 8.8e-19 PF01551: Peptidase_M23" amino acids 138 to 231 (94 residues), 109 bits, see alignment E=1.1e-35

Best Hits

Swiss-Prot: 48% identical to YGER_ECOLI: Uncharacterized lipoprotein YgeR (ygeR) from Escherichia coli (strain K12)

KEGG orthology group: None (inferred from 88% identity to bgf:BC1003_2450)

MetaCyc: 48% identical to amidase activator (Escherichia coli K-12 substr. MG1655)

Predicted SEED Role

"Membrane proteins related to metalloendopeptidases"

Sequence Analysis Tools

PaperBLAST (search for papers about homologs of this protein)

Search CDD (the Conserved Domains Database, which includes COG and superfam)

Search structures

Predict protein localization: PSORTb (Gram-negative bacteria)

Predict transmembrane helices and signal peptides: Phobius

Check the current SEED with FIGfam search

Find homologs in fast.genomics or the ENIGMA genome browser

See A0A2Z5MCH2 at UniProt or InterPro

Protein Sequence (238 amino acids)

>H281DRAFT_04431 Membrane-bound metallopeptidase (Paraburkholderia bryophila 376MFSha3.1)
MSETTRIIKRLACVSLVALIAACGSAPVGPGFYRVERGDTLSKIARSHHQSVQSIVRWNN
LTNPDSIEVGQVLRVDPPNGAASTNGAVRSSGNGSASASAAPRSAPVESAPSSPPASSIS
LVWPTNGNVIRGFDGGNSKGIDISAPAGTPVVAAAAGTVVYAGNGLRGYGNLLILKHNAE
YLTAYAHNRVLFVKEGETVAQGQKIAEVGDTDTNRVMLHFELRYQGRSIDPSRALPAR