Protein Info for H281DRAFT_04408 in Paraburkholderia bryophila 376MFSha3.1

Annotation: membrane protease FtsH catalytic subunit

These analyses and tools can help you predict a protein's function, but be skeptical. For enzymes, over 10% of annotations from KEGG or SEED are probably incorrect. For other types of proteins, the error rates may be much higher. MetaCyc and Swiss-Prot have low error rates, but the best hits in these databases are often quite distant, so this protein's function may not be the same. TIGRFam has low error rates. Finally, many experimentally-characterized proteins are not in any of these databases. To find relevant papers, use PaperBLAST.

Protein Families and Features

1 50 100 150 200 250 300 350 400 450 500 550 600 629 signal peptide" amino acids 1 to 25 (25 residues), see Phobius details transmembrane" amino acids 101 to 121 (21 residues), see Phobius details PF06480: FtsH_ext" amino acids 11 to 92 (82 residues), 44.4 bits, see alignment E=5.1e-15 TIGR01241: ATP-dependent metallopeptidase HflB" amino acids 105 to 592 (488 residues), 762.4 bits, see alignment E=1e-233 PF06068: TIP49" amino acids 158 to 223 (66 residues), 25.4 bits, see alignment E=2.4e-09 PF07728: AAA_5" amino acids 189 to 309 (121 residues), 23.5 bits, see alignment E=1.4e-08 PF00004: AAA" amino acids 190 to 322 (133 residues), 161.4 bits, see alignment E=4.7e-51 PF17862: AAA_lid_3" amino acids 345 to 389 (45 residues), 54.9 bits, see alignment 1.5e-18 PF01434: Peptidase_M41" amino acids 404 to 591 (188 residues), 226.4 bits, see alignment E=8.7e-71

Best Hits

Swiss-Prot: 82% identical to FTSH_CUPMC: ATP-dependent zinc metalloprotease FtsH (ftsH) from Cupriavidus metallidurans (strain ATCC 43123 / DSM 2839 / NBRC 102507 / CH34)

KEGG orthology group: K03798, cell division protease FtsH [EC: 3.4.24.-] (inferred from 100% identity to bgf:BC1003_2471)

Predicted SEED Role

"Cell division protein FtsH (EC 3.4.24.-)" in subsystem Bacterial Cell Division (EC 3.4.24.-)

Isozymes

Compare fitness of predicted isozymes for: 3.4.24.-

Use Curated BLAST to search for 3.4.24.-

Sequence Analysis Tools

PaperBLAST (search for papers about homologs of this protein)

Search CDD (the Conserved Domains Database, which includes COG and superfam)

Search structures

Predict protein localization: PSORTb (Gram-negative bacteria)

Predict transmembrane helices and signal peptides: Phobius

Check the current SEED with FIGfam search

Find homologs in fast.genomics or the ENIGMA genome browser

See A0A2Z5MEE4 at UniProt or InterPro

Protein Sequence (629 amino acids)

>H281DRAFT_04408 membrane protease FtsH catalytic subunit (Paraburkholderia bryophila 376MFSha3.1)
LNNNMFSKAAVWLVIALVLFTVFKQFDKPRVQEGVSYSQFMDDAKNGKVKNVIVQGRNLT
VTPADGQKYQIVSPGDIWMVGDLMKYGVQVSGKADDEPNALVSALYYLGPTILIIGFWFY
MMRQMQGGGKGGAFSFGKSRARLIDENNNAINFTDVAGCDEAKEEVSELVDFLRDPQKFQ
KLGGRIPRGVLLVGPPGTGKTLLARAIAGEAKVPFFSISGSDFVEMFVGVGAARVRDMFE
QAKKHAPCIVFIDEIDAVGRHRGAGMGGGNDEREQTLNQMLVEMDGFEANSGVIVIAATN
RSDVLDKALLRPGRFDRQVYVGLPDIRGREHIMKVHLRKVPISNDVDAAVIARGTPGFSG
ADLANLVNEAALFAARRGKRIVEMTDFEDAKDKIFMGPERKSAVIREESKRATAYHESGH
AVIAKLLPKADPVHKVTIIPRGRALGVTWQLPEHDNETYSKDYLLDRLAILFGGRVAEEL
FLNLISTGASDDFNKATQTARAMVARFGMTDALGPMVYVDDENDATPFGRGFTRTISEAT
QQKVDAEIRRVLDEQYNLAKRLLDENRDKVEAMTAALMEWETIDADQINDIMAGRPPRSP
KSSPPSASDASSGGSPGTEVKPGSATAPA