Protein Info for H281DRAFT_04231 in Paraburkholderia bryophila 376MFSha3.1

Annotation: haloacid dehalogenase superfamily, subfamily IA, variant 3 with third motif having DD or ED

These analyses and tools can help you predict a protein's function, but be skeptical. For enzymes, over 10% of annotations from KEGG or SEED are probably incorrect. For other types of proteins, the error rates may be much higher. MetaCyc and Swiss-Prot have low error rates, but the best hits in these databases are often quite distant, so this protein's function may not be the same. TIGRFam has low error rates. Finally, many experimentally-characterized proteins are not in any of these databases. To find relevant papers, use PaperBLAST.

Protein Families and Features

1 50 100 150 200 228 PF00702: Hydrolase" amino acids 2 to 176 (175 residues), 77.8 bits, see alignment E=2.2e-25 PF13419: HAD_2" amino acids 6 to 181 (176 residues), 75.5 bits, see alignment E=9.1e-25 TIGR01509: HAD hydrolase, family IA, variant 3" amino acids 76 to 181 (106 residues), 64.9 bits, see alignment E=9.7e-22 PF13242: Hydrolase_like" amino acids 138 to 182 (45 residues), 34 bits, see alignment 3.4e-12

Best Hits

KEGG orthology group: None (inferred from 93% identity to bug:BC1001_2968)

Predicted SEED Role

"Hydrolase in polyol utilization gene cluster, haloacid dehalogenase-like family" in subsystem Mannitol Utilization or Ribitol, Xylitol, Arabitol, Mannitol and Sorbitol utilization

Sequence Analysis Tools

PaperBLAST (search for papers about homologs of this protein)

Search CDD (the Conserved Domains Database, which includes COG and superfam)

Search structures

Predict protein localization: PSORTb (Gram-negative bacteria)

Predict transmembrane helices and signal peptides: Phobius

Check the current SEED with FIGfam search

Find homologs in fast.genomics or the ENIGMA genome browser

See A0A2Z5MI81 at UniProt or InterPro

Protein Sequence (228 amino acids)

>H281DRAFT_04231 haloacid dehalogenase superfamily, subfamily IA, variant 3 with third motif having DD or ED (Paraburkholderia bryophila 376MFSha3.1)
MIDHLICDCDGVLVDSEVIADRVMFETLSATFPGLDFEPIVKTAFGQQTSRFLEGIEKAF
DIALPPDFLNTIEHNVELALAASLSPINGVRTALQRVTLPAAVVSNSRMARVTASVQRAG
LQQIFGDRIFSAEQVARPKPFPDVYLFAAQTLGVEPSRCVVVEDSVAGLNAARAAGMKTI
AFVGASHIPDGYADALRKMGMTRIMKHMDELPALLEGGVRGEFGDVQS