Protein Info for H281DRAFT_04180 in Paraburkholderia bryophila 376MFSha3.1

Annotation: two component transcriptional regulator, winged helix family

These analyses and tools can help you predict a protein's function, but be skeptical. For enzymes, over 10% of annotations from KEGG or SEED are probably incorrect. For other types of proteins, the error rates may be much higher. MetaCyc and Swiss-Prot have low error rates, but the best hits in these databases are often quite distant, so this protein's function may not be the same. TIGRFam has low error rates. Finally, many experimentally-characterized proteins are not in any of these databases. To find relevant papers, use PaperBLAST.

Protein Families and Features

1 50 100 150 220 PF00072: Response_reg" amino acids 3 to 111 (109 residues), 108.7 bits, see alignment E=1.8e-35 PF00486: Trans_reg_C" amino acids 146 to 215 (70 residues), 74.4 bits, see alignment E=6.5e-25

Best Hits

Swiss-Prot: 52% identical to QSEB_ECOLI: Transcriptional regulatory protein QseB (qseB) from Escherichia coli (strain K12)

KEGG orthology group: None (inferred from 98% identity to bgf:BC1003_2852)

Predicted SEED Role

"Two-component system response regulator QseB" in subsystem Orphan regulatory proteins

Sequence Analysis Tools

PaperBLAST (search for papers about homologs of this protein)

Search CDD (the Conserved Domains Database, which includes COG and superfam)

Search structures

Predict protein localization: PSORTb (Gram-negative bacteria)

Predict transmembrane helices and signal peptides: Phobius

Check the current SEED with FIGfam search

Find homologs in fast.genomics or the ENIGMA genome browser

See A0A2Z5MDI5 at UniProt or InterPro

Protein Sequence (220 amino acids)

>H281DRAFT_04180 two component transcriptional regulator, winged helix family (Paraburkholderia bryophila 376MFSha3.1)
MRILLVEDDRMIAEGVRKALRGEGFAVDWVEDGEAALSAAGSQPYDLVLLDLGLPKRDGL
DVLRTLRARGHALPVLIVTARDAVADRVKGLDAGADDYLVKPFDLDELGARMRALIRRQS
GRSDSTIRHANLTLDPASHQVTLDGAPVALSAREFALLEALLARPGAVLSKSQLEEKMYG
WGEEIGSNTVEVYIHALRKKLGADLIRNVRGLGYMIAKEA