Protein Info for H281DRAFT_04170 in Paraburkholderia bryophila 376MFSha3.1

Annotation: multidrug efflux pump

These analyses and tools can help you predict a protein's function, but be skeptical. For enzymes, over 10% of annotations from KEGG or SEED are probably incorrect. For other types of proteins, the error rates may be much higher. MetaCyc and Swiss-Prot have low error rates, but the best hits in these databases are often quite distant, so this protein's function may not be the same. TIGRFam has low error rates. Finally, many experimentally-characterized proteins are not in any of these databases. To find relevant papers, use PaperBLAST.

Protein Families and Features

1 100 200 300 400 500 600 700 800 900 1000 1073 transmembrane" amino acids 12 to 31 (20 residues), see Phobius details amino acids 340 to 359 (20 residues), see Phobius details amino acids 366 to 388 (23 residues), see Phobius details amino acids 395 to 415 (21 residues), see Phobius details amino acids 438 to 458 (21 residues), see Phobius details amino acids 470 to 496 (27 residues), see Phobius details amino acids 540 to 558 (19 residues), see Phobius details amino acids 873 to 891 (19 residues), see Phobius details amino acids 898 to 918 (21 residues), see Phobius details amino acids 924 to 947 (24 residues), see Phobius details amino acids 973 to 991 (19 residues), see Phobius details amino acids 1002 to 1027 (26 residues), see Phobius details TIGR00915: RND transporter, hydrophobe/amphiphile efflux-1 (HAE1) family" amino acids 1 to 1044 (1044 residues), 1718.3 bits, see alignment E=0 PF00873: ACR_tran" amino acids 1 to 1029 (1029 residues), 1324.2 bits, see alignment E=0

Best Hits

Swiss-Prot: 66% identical to ACRB_ECOLI: Multidrug efflux pump subunit AcrB (acrB) from Escherichia coli (strain K12)

KEGG orthology group: K03296, hydrophobic/amphiphilic exporter-1 (mainly G- bacteria), HAE1 family (inferred from 67% identity to abo:ABO_0964)

MetaCyc: 61% identical to multidrug efflux pump RND permease AcrD (Escherichia coli K-12 substr. MG1655)
TRANS-RXN-1551; TRANS-RXN-1552; TRANS-RXN-360

Predicted SEED Role

"RND efflux system, inner membrane transporter CmeB" in subsystem Multidrug Resistance Efflux Pumps or Multidrug efflux pump in Campylobacter jejuni (CmeABC operon)

Sequence Analysis Tools

PaperBLAST (search for papers about homologs of this protein)

Search CDD (the Conserved Domains Database, which includes COG and superfam)

Search structures

Predict protein localization: PSORTb (Gram-negative bacteria)

Predict transmembrane helices and signal peptides: Phobius

Check the current SEED with FIGfam search

Find homologs in fast.genomics or the ENIGMA genome browser

See A0A2Z5MDH5 at UniProt or InterPro

Protein Sequence (1073 amino acids)

>H281DRAFT_04170 multidrug efflux pump (Paraburkholderia bryophila 376MFSha3.1)
MAKFFIDRPIFAWVIAIILMLAGIASVFTLPIAQYPTIAPPAVQISATYPGASAKTVENT
VTQVIEQQMSGLDHLLYLSSTSDDSGTATITLTFAAGTNPDIAQVQVQNKLQLATPLLPQ
AVQQLGTKVTKSSSSFLLVMAFVSEDGSMNKYDLANYVASNIQDPVSRIDGVGTVTLFGS
QYAMRIWLDANKLTNFGLTPVDVQTALQAQNVQVAGGSLGGTPSVPGQVLQATITEATLL
NTPEQFGNVLLKVNPDGSQVRIKDVARVELGGENYNFDTKYNGQPTAGFGIQLATGANAL
ATAKAVRAKVAELSKYFPHGLVVQYPYDTTPFVRLSIEEVVKTLLEGIVLVFLVMYLFLQ
NLRATLIPTIAVPVVLLGTFAVMSMVGFSINTLSMFGLVLAIGLLVDDAIVVVENVERVM
AEEGLSPREATRKAMDQITGALVGVALVLSAVFVPVAFSGGSVGAIYRQFSLTIVAAMVL
SVLVALILTPALCATILKPIPQGHHEEKKGFFGWFNRNFNKSRDKYHSGVHHVIKRSGRW
LIIYMVVIFAVGLLFVKLPKSFLPDEDQGTMFVLVQTPSGSTQETTARALKDVSDYLLNG
EKAIVESTFTVNGFSFAGRGQNAGLVFVRMKDYAQRQHADEKVQALVGRLFMHFGSYKGA
LVYPVNPPSIPELGTAAGFDFELQDRAGVGHEKLMQARNMLLGMAAQDPTLAQVRPNGLN
DTPQFKVNIDHEKASALGVSLSAIDQTFSIAWASQYVNNFLDTDGRIKKVYLQGDAPFRM
TPEDLNTWYVRNTAGGMVPFSSFASGQWTYGSPKLERYNGISAVEIQGAAAPGKSTGQAM
TAMEALVAKLPAGVGYEWTGLSLQERQSGSQAPILYGISILVVFLCLAALYESWSIPFSV
IMVVPLGVIGALLAATLRGLENDVFFQVGLLTTVGLSAKNAILIVEFARELQLSEGMGPV
EAALEAARLRLRPILMTSLAFILGVMPLAISNGAGSASQHAIGTGVIGGMLTATFLAIFM
IPMFFVVIRAKFGGDKEDPDAALAHYNEHHPHDPQGGGAAGGSDTNGSGKDGH