Protein Info for H281DRAFT_04105 in Paraburkholderia bryophila 376MFSha3.1

Annotation: ATP-dependent Clp protease proteolytic subunit ClpP

These analyses and tools can help you predict a protein's function, but be skeptical. For enzymes, over 10% of annotations from KEGG or SEED are probably incorrect. For other types of proteins, the error rates may be much higher. MetaCyc and Swiss-Prot have low error rates, but the best hits in these databases are often quite distant, so this protein's function may not be the same. TIGRFam has low error rates. Finally, many experimentally-characterized proteins are not in any of these databases. To find relevant papers, use PaperBLAST.

Protein Families and Features

1 50 100 150 219 transmembrane" amino acids 98 to 115 (18 residues), see Phobius details TIGR00493: ATP-dependent Clp endopeptidase, proteolytic subunit ClpP" amino acids 12 to 201 (190 residues), 321.4 bits, see alignment E=1e-100 PF00574: CLP_protease" amino acids 23 to 202 (180 residues), 280.7 bits, see alignment E=2.7e-88

Best Hits

Swiss-Prot: 92% identical to CLPP1_PARXL: ATP-dependent Clp protease proteolytic subunit 1 (clpP1) from Paraburkholderia xenovorans (strain LB400)

KEGG orthology group: K01358, ATP-dependent Clp protease, protease subunit [EC: 3.4.21.92] (inferred from 92% identity to bpy:Bphyt_3190)

MetaCyc: 64% identical to ClpP1 (Synechococcus elongatus PCC 7942 = FACHB-805)

Predicted SEED Role

"ATP-dependent Clp protease proteolytic subunit (EC 3.4.21.92)" in subsystem Proteasome bacterial or Proteolysis in bacteria, ATP-dependent or cAMP signaling in bacteria (EC 3.4.21.92)

Isozymes

Compare fitness of predicted isozymes for: 3.4.21.92

Use Curated BLAST to search for 3.4.21.92

Sequence Analysis Tools

PaperBLAST (search for papers about homologs of this protein)

Search CDD (the Conserved Domains Database, which includes COG and superfam)

Search structures

Predict protein localization: PSORTb (Gram-negative bacteria)

Predict transmembrane helices and signal peptides: Phobius

Check the current SEED with FIGfam search

Find homologs in fast.genomics or the ENIGMA genome browser

See A0A2Z5MDC0 at UniProt or InterPro

Protein Sequence (219 amino acids)

>H281DRAFT_04105 ATP-dependent Clp protease proteolytic subunit ClpP (Paraburkholderia bryophila 376MFSha3.1)
MHSNYASVTDLGLVPTVIEQSGRGERAYDIYSRLLRERIVFLVGPVNEQSASLIVAQLLF
LESENPDKDISFYINSPGGSVYDGLAIYDTMQFIKPEVSTLCTGFAASMGTFLLCAGQRG
KRYALPNARIMIHQPSGGSQGTAADIDIQAKEVLYLRERLNAMMAERTGRSIEEIARDTD
RDNFMSALAAKSYGLVDEVLETRAALSPFPAAPDKRHDL