Protein Info for H281DRAFT_04096 in Paraburkholderia bryophila 376MFSha3.1

Annotation: Aldo/keto reductase

These analyses and tools can help you predict a protein's function, but be skeptical. For enzymes, over 10% of annotations from KEGG or SEED are probably incorrect. For other types of proteins, the error rates may be much higher. MetaCyc and Swiss-Prot have low error rates, but the best hits in these databases are often quite distant, so this protein's function may not be the same. TIGRFam has low error rates. Finally, many experimentally-characterized proteins are not in any of these databases. To find relevant papers, use PaperBLAST.

Protein Families and Features

• PF00248: Aldo_ket_red
  • amino acids 18 to 267 (250 residues), 185 bits, E=8.7e-59

Best Hits

Swiss-Prot: 54% identical to YEAE_ECOLI: Uncharacterized protein YeaE (yeaE) from Escherichia coli (strain K12)

KEGG orthology group: None (inferred from 92% identity to bgf:BC1003_2767)

MetaCyc: 54% identical to methylglyoxal reductase YeaE (Escherichia coli K-12 substr. MG1655)
Aldehyde reductase. [EC: 1.1.1.21]

Predicted SEED Role

"Oxidoreductase, aldo/keto reductase family"

MetaCyc Pathways

• L-arabinose degradation II (2/3 steps found)
• methylglyoxal degradation III (1/2 steps found)
• superpathway of methylglyoxal degradation (4/8 steps found)
• detoxification of reactive carbonyls in chloroplasts (4/10 steps found)
• superpathway of pentose and pentitol degradation (21/42 steps found)

KEGG Metabolic Maps

• Fructose and mannose metabolism
• Galactose metabolism
• Glycerolipid metabolism
• Pentose and glucuronate interconversions
• Pyruvate metabolism

Isozymes

No predicted isozymes

Use Curated BLAST to search for 1.1.1.21

Sequence Analysis Tools

See A0A2Z5MDM5 at UniProt or InterPro

Protein Sequence (281 amino acids)

>H281DRAFT_04096 Aldo/keto reductase (Paraburkholderia bryophila 376MFSha3.1)
MTTDIASVSLPDGERIPKLGQGTWEMGEQPARRAAEIAAIRLGVELGMTLVDTAEMYGDG
ATELLLGEALAGLRDQVFLVSKVYPHNASRRGVIAACEQSLKRLKTDRLDLYLLHWRGSI
PLEETVAGFEALRDAGKIRHWGVSNFDTEDMEELIATPGGTACATDQILYNVARRGPEFD
LLPWLAERNMPAMAYSPVDHARLPKRSPLDDIASARGVSVFQVALAWVLQQPGVFAIPKT
GRVEHVRDNHRALQLRLDAQELAAIDSYFKPPRGKRPLEML