Protein Info for H281DRAFT_04022 in Paraburkholderia bryophila 376MFSha3.1

Annotation: 6,7-dimethyl-8-ribityllumazine synthase

These analyses and tools can help you predict a protein's function, but be skeptical. For enzymes, over 10% of annotations from KEGG or SEED are probably incorrect. For other types of proteins, the error rates may be much higher. MetaCyc and Swiss-Prot have low error rates, but the best hits in these databases are often quite distant, so this protein's function may not be the same. TIGRFam has low error rates. Finally, many experimentally-characterized proteins are not in any of these databases. To find relevant papers, use PaperBLAST.

Protein Families and Features

1 50 100 167 PF00885: DMRL_synthase" amino acids 14 to 147 (134 residues), 168.3 bits, see alignment E=4.5e-54 TIGR00114: 6,7-dimethyl-8-ribityllumazine synthase" amino acids 15 to 146 (132 residues), 138.9 bits, see alignment E=5.9e-45

Best Hits

Swiss-Prot: 98% identical to RISB_PARPJ: 6,7-dimethyl-8-ribityllumazine synthase (ribH) from Paraburkholderia phytofirmans (strain DSM 17436 / LMG 22146 / PsJN)

KEGG orthology group: K00794, 6,7-dimethyl-8-ribityllumazine synthase [EC: 2.5.1.78] (inferred from 97% identity to bge:BC1002_2322)

MetaCyc: 45% identical to 6,7-dimethyl-8-ribityllumazine synthase monomer (Bacillus subtilis)
LUMAZINESYN-RXN [EC: 2.5.1.78]

Predicted SEED Role

"6,7-dimethyl-8-ribityllumazine synthase (EC 2.5.1.78)" (EC 2.5.1.78)

MetaCyc Pathways

Isozymes

No predicted isozymes

Use Curated BLAST to search for 2.5.1.78

Sequence Analysis Tools

PaperBLAST (search for papers about homologs of this protein)

Search CDD (the Conserved Domains Database, which includes COG and superfam)

Search structures

Predict protein localization: PSORTb (Gram-negative bacteria)

Predict transmembrane helices and signal peptides: Phobius

Check the current SEED with FIGfam search

Find homologs in fast.genomics or the ENIGMA genome browser

See A0A2Z5MD34 at UniProt or InterPro

Protein Sequence (167 amino acids)

>H281DRAFT_04022 6,7-dimethyl-8-ribityllumazine synthase (Paraburkholderia bryophila 376MFSha3.1)
MEIGQYQPNLDGDGLRIGIVQARFNEPVCNGLADSCIEELERLGVTGEDVLLVTVPGALE
IPLALQKLAESAQFDALIALGAVIRGETYHFELVSNESGAGITRIGLDFGIPVANAVLTT
ENDEQAVARMTEKGRDAARVAVEMANLAVALEQLGGDEEEDEEEEEA