Protein Info for H281DRAFT_03988 in Paraburkholderia bryophila 376MFSha3.1

Annotation: alanyl aminopeptidase. Metallo peptidase. MEROPS family M01

These analyses and tools can help you predict a protein's function, but be skeptical. For enzymes, over 10% of annotations from KEGG or SEED are probably incorrect. For other types of proteins, the error rates may be much higher. MetaCyc and Swiss-Prot have low error rates, but the best hits in these databases are often quite distant, so this protein's function may not be the same. TIGRFam has low error rates. Finally, many experimentally-characterized proteins are not in any of these databases. To find relevant papers, use PaperBLAST.

Protein Families and Features

1 50 100 150 200 250 300 350 400 450 500 550 600 650 700 750 800 850 924 TIGR02414: aminopeptidase N" amino acids 37 to 923 (887 residues), 1235.3 bits, see alignment E=0 PF17900: Peptidase_M1_N" amino acids 106 to 213 (108 residues), 54.3 bits, see alignment E=3.8e-18 PF01433: Peptidase_M1" amino acids 253 to 476 (224 residues), 181.2 bits, see alignment E=4.4e-57 PF11940: DUF3458" amino acids 481 to 590 (110 residues), 91.9 bits, see alignment E=5.7e-30 PF17432: DUF3458_C" amino acids 594 to 924 (331 residues), 409.9 bits, see alignment E=1.8e-126

Best Hits

KEGG orthology group: K01256, aminopeptidase N [EC: 3.4.11.2] (inferred from 94% identity to bug:BC1001_2696)

Predicted SEED Role

"Membrane alanine aminopeptidase N (EC 3.4.11.2)" (EC 3.4.11.2)

KEGG Metabolic Maps

Isozymes

Compare fitness of predicted isozymes for: 3.4.11.2

Use Curated BLAST to search for 3.4.11.2

Sequence Analysis Tools

PaperBLAST (search for papers about homologs of this protein)

Search CDD (the Conserved Domains Database, which includes COG and superfam)

Search structures

Predict protein localization: PSORTb (Gram-negative bacteria)

Predict transmembrane helices and signal peptides: Phobius

Check the current SEED with FIGfam search

Find homologs in fast.genomics or the ENIGMA genome browser

See A0A2Z5MFA8 at UniProt or InterPro

Protein Sequence (924 amino acids)

>H281DRAFT_03988 alanyl aminopeptidase. Metallo peptidase. MEROPS family M01 (Paraburkholderia bryophila 376MFSha3.1)
MARQARLTRLRAPAARVPSLQNAMADTATPNVIRRADYAPPAFLIDTVALEFDLLPERTV
VKNTMRVRRNPDASRAAHLELMGEQLEFVSATLDGQPFANAHAHEHGLVLDNVPEKFELT
LTSICNPAANTTLSGLYVSSGNFFTQCEAEGFRRITYFLDRPDVMATYTVTLRASKADYP
VLLSNGNLLEEGDLPDGRHFARWEDPFRKPSYLFALVAGKLVALEERVKTGSGKEKLLQV
WVEPHDLDKTRHAMDSLIHSIRWDEERFGLELDLDRFMIVAVSDFNMGAMENKGLNIFNT
KYVLANPETATDSDFANIEAVVGHEYFHNWTGNRVTCRDWFQLSLKEGLTVFRDQEFSAD
MAAGEADGSDEAARATKRIEDVRVLRQMQFAEDAGPMAHPVRPESYVEINNFYTMTVYEK
GSEVVRMYQTLFGREGFRKGMDLYFKRHDGQAVTCDDFRHALADANGRDLAQFERWYSQA
GTPRVTVRTRYDAAQQRYSVTLTQGYGDAAPAARETQKGPLLIPFAIGLIGKDGKDLPLQ
LESEPKASDSTTRVLEFTQTEQTFTFVNVAQEPLPSLLRNFSAPVIVEYDYSADQLAFLL
AHDSDPFNRWEAGQRLATRELLTLAGRAASGEQLQLDDSVAAAFARVLTDESLSPAFREL
ALMLPSEAYLAEQMAESNPAAVHAARQFVRKRLANALKNDWLKIYEQHRTPGPYEATPAA
AGHRALKNLALSYLTELDDPSETVRLASAQYDAANNMTDRAAALSALLNASAANGGSAEA
QHALDDFYRRFEKEPLVIDKWFALQATQRGSAQRPVIDVVRKLMTHPAFNLKNPNRARSL
IFSFCAANPAQFHAEDGSGYAFWADQVIALDAINPQVAARLARSLELWRRFTPTLREGMR
AALEKVASQVKSRDVREIVEKALA