Protein Info for H281DRAFT_03970 in Paraburkholderia bryophila 376MFSha3.1

Annotation: 3-oxoacyl-[acyl-carrier-protein] synthase-1

These analyses and tools can help you predict a protein's function, but be skeptical. For enzymes, over 10% of annotations from KEGG or SEED are probably incorrect. For other types of proteins, the error rates may be much higher. MetaCyc and Swiss-Prot have low error rates, but the best hits in these databases are often quite distant, so this protein's function may not be the same. TIGRFam has low error rates. Finally, many experimentally-characterized proteins are not in any of these databases. To find relevant papers, use PaperBLAST.

Protein Families and Features

Best Hits

Swiss-Prot: 49% identical to FABB_PSEAB: 3-oxoacyl-[acyl-carrier-protein] synthase 1 (fabB) from Pseudomonas aeruginosa (strain UCBPP-PA14)

KEGG orthology group: K00647, 3-oxoacyl-[acyl-carrier-protein] synthase I [EC: 2.3.1.41] (inferred from 91% identity to bug:BC1001_2678)

Predicted SEED Role

"3-oxoacyl-[acyl-carrier-protein] synthase, KASI (EC 2.3.1.41)" in subsystem Fatty Acid Biosynthesis FASII (EC 2.3.1.41)

MetaCyc Pathways

superpathway of fatty acids biosynthesis (E. coli) (50/53 steps found)
palmitate biosynthesis III (28/29 steps found)
superpathway of fatty acid biosynthesis II (plant) (38/43 steps found)
palmitate biosynthesis II (type II fatty acid synthase) (29/31 steps found)
tetradecanoate biosynthesis (mitochondria) (23/25 steps found)
superpathway of unsaturated fatty acids biosynthesis (E. coli) (19/20 steps found)
oleate biosynthesis IV (anaerobic) (14/14 steps found)
octanoyl-[acyl-carrier protein] biosynthesis (mitochondria, yeast) (12/12 steps found)
palmitoleate biosynthesis I (from (5Z)-dodec-5-enoate) (9/9 steps found)
superpathway of fatty acid biosynthesis I (E. coli) (14/16 steps found)
biotin biosynthesis I (13/15 steps found)
fatty acid elongation -- saturated (5/5 steps found)
gondoate biosynthesis (anaerobic) (4/4 steps found)
8-amino-7-oxononanoate biosynthesis I (9/11 steps found)
(5Z)-dodecenoate biosynthesis I (5/6 steps found)
stearate biosynthesis II (bacteria and plants) (5/6 steps found)
superpathway of fatty acid biosynthesis initiation (4/5 steps found)
(5Z)-dodecenoate biosynthesis II (4/6 steps found)
stearate biosynthesis IV (4/6 steps found)
fatty acid biosynthesis initiation (mitochondria) (2/4 steps found)
streptorubin B biosynthesis (20/34 steps found)
mycolate biosynthesis (25/205 steps found)
superpathway of mycolate biosynthesis (26/239 steps found)

KEGG Metabolic Maps

Fatty acid biosynthesis

Isozymes

Compare fitness of predicted isozymes for: 2.3.1.41

Use Curated BLAST to search for 2.3.1.41

Sequence Analysis Tools

PaperBLAST (search for papers about homologs of this protein)

Search CDD (the Conserved Domains Database, which includes COG and superfam)

Search structures

Predict protein localization: PSORTb (Gram-negative bacteria)

Predict transmembrane helices and signal peptides: Phobius

Check the current SEED with FIGfam search

Find homologs in fast.genomics or the ENIGMA genome browser

See A0A2Z5MED5 at UniProt or InterPro

Protein Sequence (412 amino acids)

>H281DRAFT_03970 3-oxoacyl-[acyl-carrier-protein] synthase-1 (Paraburkholderia bryophila 376MFSha3.1)
MSVALQRVVVTGMGIVSCLGNSLDEVSAALRAGKSRIERVEAWRERGFASQVAGVASVAN
EAPFERKLERFMGDTARFACHAARKAIDDAGLDAAMLRSPLAGTVIGSGVGTMSSYDAAM
TVANTRGVDKVPPYTVPHAMSSTASANVAQVFGLEGVGYSPSSACTTSALAIGQAMQLIQ
SGRQQILLAGGSESLHDNMTLMFDAMGALSRRSNDAPERASRPYDTARDGFVIASGGGVL
VLEALDHALARGARIYAELTGFGDCTDAGMVTPRAAGIARAVRGALDEAGKRPDYINTHA
PSTPLGDVEELHALRQVFGAASERGVPAFSSTKGMTGHPLGACGAHEAIYTLLMMRDGFI
AGTTGIDSAEPEIDGMPLVRETRDARIGSAMSVSFGFGGSCASLMFEAWQGG