Protein Info for H281DRAFT_03840 in Paraburkholderia bryophila 376MFSha3.1

Annotation: urea carboxylase

These analyses and tools can help you predict a protein's function, but be skeptical. For enzymes, over 10% of annotations from KEGG or SEED are probably incorrect. For other types of proteins, the error rates may be much higher. MetaCyc and Swiss-Prot have low error rates, but the best hits in these databases are often quite distant, so this protein's function may not be the same. TIGRFam has low error rates. Finally, many experimentally-characterized proteins are not in any of these databases. To find relevant papers, use PaperBLAST.

Protein Families and Features

1 100 200 300 400 500 600 700 800 900 1000 1100 1199 PF00289: Biotin_carb_N" amino acids 1 to 109 (109 residues), 130.5 bits, see alignment E=1.5e-41 TIGR02712: urea carboxylase" amino acids 2 to 1197 (1196 residues), 1823.6 bits, see alignment E=0 PF02786: CPSase_L_D2" amino acids 116 to 319 (204 residues), 201.8 bits, see alignment E=4e-63 PF07478: Dala_Dala_lig_C" amino acids 145 to 291 (147 residues), 35.7 bits, see alignment E=2.7e-12 PF02785: Biotin_carb_C" amino acids 338 to 446 (109 residues), 114.9 bits, see alignment E=7.6e-37 TIGR00724: biotin-dependent carboxylase uncharacterized domain" amino acids 454 to 772 (319 residues), 295.8 bits, see alignment E=3.2e-92 PF02626: CT_A_B" amino acids 478 to 749 (272 residues), 310.8 bits, see alignment E=3.6e-96 PF02682: CT_C_D" amino acids 801 to 1019 (219 residues), 139.1 bits, see alignment E=6.4e-44 PF00364: Biotin_lipoyl" amino acids 1137 to 1196 (60 residues), 55.4 bits, see alignment 1.8e-18

Best Hits

Predicted SEED Role

"Urea carboxylase (EC 6.3.4.6)" in subsystem Urea decomposition (EC 6.3.4.6)

MetaCyc Pathways

KEGG Metabolic Maps

Isozymes

No predicted isozymes

Use Curated BLAST to search for 6.3.4.6

Sequence Analysis Tools

PaperBLAST (search for papers about homologs of this protein)

Search CDD (the Conserved Domains Database, which includes COG and superfam)

Search structures

Predict protein localization: PSORTb (Gram-negative bacteria)

Predict transmembrane helices and signal peptides: Phobius

Check the current SEED with FIGfam search

Find homologs in fast.genomics or the ENIGMA genome browser

See A0A2Z5MLL4 at UniProt or InterPro

Protein Sequence (1199 amino acids)

>H281DRAFT_03840 urea carboxylase (Paraburkholderia bryophila 376MFSha3.1)
MFEKILIANRGAIACRILRTLRELNVTGVSVFSEADRASRHVSEAPIAHELGDGPAAMTY
LDSTKILEIARCEGVQAIHPGYGFLSENAAFGEACEAAGIAFIGPTPAQLRAFGLKHTAR
EIAGEQGVPMLNGTGLLEDLPAALNAAESIGYPVMLKSTAGGGGIGMRVCWHADELSAHF
DAVKRLGENNFSDSGVFLEKYIERARHLEVQVFGDGKGDAIALGVRDCSVQRRNQKVLEE
TPAPCLPEGIAQALCDAAVKLAKAVDYRSAGTVEFVYDSTAQQFYFLEVNTRLQVEHGVT
EQVWGVDLVRWMIELAAGTLAPLNELAASLTPRGHAIQARLYAEDPGRDFIPSPGLLTHV
AFPQADGSALRIDTWIESGCEVPPYFDPMLAKIIAWSPTREEARHALNDALQNTRIFGVE
TNRDYLRQILDDEPFASGEPWTRCLEGLKYRASTIEVVSGGTQTTVQDFPGRQGFWAVGI
PPSGPMDDRAMRLGNRLLGNAPEAAALEITMSGPTLRFNTDAVIAITGAEIPVLLDDVTQ
PLNTSVYVRAGSVLALGTIRGAGARAYLCVRGGLDVALYLGSRSTFTLGQFGGHGGRAVR
AGDVLHLYPLQDTQAGAALSNVPTLESVRTIRVIYGPHGAPEYFSARYIEQFLDTEWEIH
FNSSRTGVRLIGPKPEWAREDGGEAGLHPSNIHDNPYAVGAVDFTGDMPVILGPDGPSLG
GFVCPVTIIEADLWHIGQLKAGDKVRFVPVEIGHAREAARERIRELESLAITQCAPVERR
SSLTSPIVLDSGAADERLVARLSGDTHLLLEIGPPELDLVSRFRGHALMQALEAKALPGV
IDLTPGIRSLQIHYRPEDLSLAQLLGIVGEAWEQVLLMKDLRVPSRVVHIPLSWDDPACQ
LAIEKYMTTVRKDAPWCPSNLEFIRRINDLESIDAVRRIVFDANYLVMGLGDVYLGAPVA
TPLDPRHRLVTTKYNPARTWTAENSVGIGGAYLCVYGMEGPGGYQFVGRTLQMWNRYRKV
ADFAGQPYLLRFFDQIRFYEVSSEELLRIRADFPLGRYPLRIEESELSLPDYQAFLASES
ASIEEFRSRQQAAFEAERERWREAGTSEEAIEAPVAEDAQLAPLEDGEVSVDSEIAGSLW
QVKVKPGDVVAADDILLIIESMKMEISVCAPCAGTVGEIYVGPGSPVRAGQRIAVIERH