Protein Info for H281DRAFT_03801 in Paraburkholderia bryophila 376MFSha3.1

Annotation: two component transcriptional regulator, winged helix family

These analyses and tools can help you predict a protein's function, but be skeptical. For enzymes, over 10% of annotations from KEGG or SEED are probably incorrect. For other types of proteins, the error rates may be much higher. MetaCyc and Swiss-Prot have low error rates, but the best hits in these databases are often quite distant, so this protein's function may not be the same. TIGRFam has low error rates. Finally, many experimentally-characterized proteins are not in any of these databases. To find relevant papers, use PaperBLAST.

Protein Families and Features

1 50 100 150 200 245 PF00072: Response_reg" amino acids 24 to 133 (110 residues), 101.5 bits, see alignment E=3.2e-33 PF00486: Trans_reg_C" amino acids 166 to 238 (73 residues), 57.3 bits, see alignment E=1.4e-19

Best Hits

Swiss-Prot: 47% identical to TCTD_SALTS: Transcriptional regulatory protein tctD (tctD) from Salmonella typhimurium (strain SL1344)

KEGG orthology group: None (inferred from 97% identity to bug:BC1001_4566)

Predicted SEED Role

"Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain"

Sequence Analysis Tools

PaperBLAST (search for papers about homologs of this protein)

Search CDD (the Conserved Domains Database, which includes COG and superfam)

Search structures

Predict protein localization: PSORTb (Gram-negative bacteria)

Predict transmembrane helices and signal peptides: Phobius

Check the current SEED with FIGfam search

Find homologs in fast.genomics or the ENIGMA genome browser

See A0A2Z5MLM9 at UniProt or InterPro

Protein Sequence (245 amino acids)

>H281DRAFT_03801 two component transcriptional regulator, winged helix family (Paraburkholderia bryophila 376MFSha3.1)
MRAAPCFYGTIDALTLAVCAMKLLLIEDNPTLAHWLAKMLEQEAFALDAVQDGDAADRLL
RTNHYDVILLDLNLPKLSGKNVLRRLRQRGDATPVLILTASGSIDEKVELLGAGADDYLV
KPFEVRELIARIKVAIRRQSPSKASEVVCGDLAFDIDTRQFTLKGAPLNVTPRERSVLET
LILRLGKTVTKPALVDAIFTLADEPSEDAVEIYISRLRKKLDGSSAAIVTLRGLGYLLRK
KEDDQ