Protein Info for H281DRAFT_03766 in Paraburkholderia bryophila 376MFSha3.1

Annotation: glucose 1-dehydrogenase

These analyses and tools can help you predict a protein's function, but be skeptical. For enzymes, over 10% of annotations from KEGG or SEED are probably incorrect. For other types of proteins, the error rates may be much higher. MetaCyc and Swiss-Prot have low error rates, but the best hits in these databases are often quite distant, so this protein's function may not be the same. TIGRFam has low error rates. Finally, many experimentally-characterized proteins are not in any of these databases. To find relevant papers, use PaperBLAST.

Protein Families and Features

1 50 100 150 200 266 signal peptide" amino acids 1 to 25 (25 residues), see Phobius details PF00106: adh_short" amino acids 9 to 207 (199 residues), 186.7 bits, see alignment E=5e-59 PF08659: KR" amino acids 11 to 197 (187 residues), 68.4 bits, see alignment E=1.2e-22 PF13561: adh_short_C2" amino acids 14 to 257 (244 residues), 221 bits, see alignment E=2.7e-69

Best Hits

KEGG orthology group: None (inferred from 93% identity to bug:BC1001_4605)

MetaCyc: 35% identical to NAD(P)+-dependent L-rhamnose 1-dehydrogenase (Azotobacter vinelandii NBRC 102612)
RXN-12158 [EC: 1.1.1.378]; L-rhamnose 1-dehydrogenase. [EC: 1.1.1.378, 1.1.1.173]

Predicted SEED Role

"Glucose 1-dehydrogenase (EC 1.1.1.47)" in subsystem D-gluconate and ketogluconates metabolism or Entner-Doudoroff Pathway (EC 1.1.1.47)

MetaCyc Pathways

KEGG Metabolic Maps

Isozymes

Compare fitness of predicted isozymes for: 1.1.1.173

Use Curated BLAST to search for 1.1.1.173 or 1.1.1.378 or 1.1.1.47

Sequence Analysis Tools

PaperBLAST (search for papers about homologs of this protein)

Search CDD (the Conserved Domains Database, which includes COG and superfam)

Search structures

Predict protein localization: PSORTb (Gram-negative bacteria)

Predict transmembrane helices and signal peptides: Phobius

Check the current SEED with FIGfam search

Find homologs in fast.genomics or the ENIGMA genome browser

See A0A2Z5MLU8 at UniProt or InterPro

Protein Sequence (266 amino acids)

>H281DRAFT_03766 glucose 1-dehydrogenase (Paraburkholderia bryophila 376MFSha3.1)
MEKLLANQFALVTGASSGIGYGVAKALADAGASVALNYHSHAESAEKLADEINQSGGAAI
AVKADVSNPADVDAMFEACRARFGTLDIVVANSGLQKDSAFAEMTLEDWQTVLATNLTGQ
FLTAQAAVKEFRRRGPTSVSKAVGKIICMSSVHEVIPWAGHVNYAASKGGIQMFMKSLAQ
EVAPERIRVNSIAPGAIRTQINRDAWDTSAARDKLLQLIPYGRVGEVEDIGKAAVWLASD
ESDYVVGTTLFVDGGMTLYPGFADNG