Protein Info for H281DRAFT_03442 in Paraburkholderia bryophila 376MFSha3.1

Annotation: mannose-6-phosphate isomerase, type 2

These analyses and tools can help you predict a protein's function, but be skeptical. For enzymes, over 10% of annotations from KEGG or SEED are probably incorrect. For other types of proteins, the error rates may be much higher. MetaCyc and Swiss-Prot have low error rates, but the best hits in these databases are often quite distant, so this protein's function may not be the same. TIGRFam has low error rates. Finally, many experimentally-characterized proteins are not in any of these databases. To find relevant papers, use PaperBLAST.

Protein Families and Features

1 50 100 150 200 250 300 350 400 450 504 TIGR01479: mannose-1-phosphate guanylyltransferase/mannose-6-phosphate isomerase" amino acids 27 to 502 (476 residues), 598.3 bits, see alignment E=5.1e-184 PF00483: NTP_transferase" amino acids 28 to 317 (290 residues), 161 bits, see alignment E=7.9e-51 PF12804: NTP_transf_3" amino acids 29 to 167 (139 residues), 33 bits, see alignment E=1.3e-11 PF01050: MannoseP_isomer" amino acids 348 to 498 (151 residues), 235 bits, see alignment E=6.8e-74 PF07883: Cupin_2" amino acids 415 to 482 (68 residues), 40.7 bits, see alignment E=3.2e-14

Best Hits

KEGG orthology group: None (inferred from 91% identity to bug:BC1001_5448)

Predicted SEED Role

"Mannose-1-phosphate guanylyltransferase (GDP) (EC 2.7.7.22)" in subsystem Alginate metabolism or Mannose Metabolism (EC 2.7.7.22)

KEGG Metabolic Maps

Isozymes

Compare fitness of predicted isozymes for: 2.7.7.22

Use Curated BLAST to search for 2.7.7.22

Sequence Analysis Tools

PaperBLAST (search for papers about homologs of this protein)

Search CDD (the Conserved Domains Database, which includes COG and superfam)

Search structures

Predict protein localization: PSORTb (Gram-negative bacteria)

Predict transmembrane helices and signal peptides: Phobius

Check the current SEED with FIGfam search

Find homologs in fast.genomics or the ENIGMA genome browser

See A0A2Z5MGP9 at UniProt or InterPro

Protein Sequence (504 amino acids)

>H281DRAFT_03442 mannose-6-phosphate isomerase, type 2 (Paraburkholderia bryophila 376MFSha3.1)
MDKVFATAGETDFEAQHVASQECPPLAQVILAGGSGTRLWPVSREQFPKQLIDVIGDKTL
LQATMNRMDDFNPLWSVVPDPVIVCGAEHYFATSEQARESGVNARIVVEPGRRDTAPALT
LAALTAASEGTDVILVAMPADHAIADLTALHKAIEIAARHADAGAIATLGVPPTGPDTGF
GYIRLGSALSDGAHRIERFVEKPAPELAAQYVESGNYWWNSGMFVVRASVWLSVIRQFQP
QIHDACVRAYEGAKVTDGCVVPDAEAFLQSPSDSIDYAVMEHLGKPESPFSGVVVPLEAG
WSDLGSWDAVWQAMEKDDCGNASSGRVLFEGATATYARSQGGRLLACVGTNDLIVVETDD
AVLVADRSHVQDIKGLVSRIKAEKSPEADAHRKVRRPWGFYDSIDQGDRFQVKRIVVMPG
ARLSLQMHHHRAEHWIVVSGTALVTRGEEQFLLGENESTYIPLGIRHRLENPGCVPLQII
EVQSGTYLGEDDIVRFDDKYGRAG