Protein Info for H281DRAFT_03268 in Paraburkholderia bryophila 376MFSha3.1

Annotation: diguanylate cyclase/phosphodiesterase

These analyses and tools can help you predict a protein's function, but be skeptical. For enzymes, over 10% of annotations from KEGG or SEED are probably incorrect. For other types of proteins, the error rates may be much higher. MetaCyc and Swiss-Prot have low error rates, but the best hits in these databases are often quite distant, so this protein's function may not be the same. TIGRFam has low error rates. Finally, many experimentally-characterized proteins are not in any of these databases. To find relevant papers, use PaperBLAST.

Protein Families and Features

1 50 100 150 200 250 300 350 400 450 500 550 600 644 transmembrane" amino acids 17 to 39 (23 residues), see Phobius details amino acids 159 to 181 (23 residues), see Phobius details PF17152: CHASE8" amino acids 41 to 149 (109 residues), 63 bits, see alignment E=3.9e-21 TIGR00254: diguanylate cyclase (GGDEF) domain" amino acids 195 to 356 (162 residues), 143.6 bits, see alignment E=2.3e-46 PF00990: GGDEF" amino acids 199 to 354 (156 residues), 157.1 bits, see alignment E=5.1e-50 PF00563: EAL" amino acids 376 to 609 (234 residues), 246.3 bits, see alignment E=4.3e-77

Best Hits

KEGG orthology group: None (inferred from 88% identity to bgf:BC1003_4077)

Predicted SEED Role

No annotation

Sequence Analysis Tools

PaperBLAST (search for papers about homologs of this protein)

Search CDD (the Conserved Domains Database, which includes COG and superfam)

Search structures

Predict protein localization: PSORTb (Gram-negative bacteria)

Predict transmembrane helices and signal peptides: Phobius

Check the current SEED with FIGfam search

Find homologs in fast.genomics or the ENIGMA genome browser

Find the best match in UniProt

Protein Sequence (644 amino acids)

>H281DRAFT_03268 diguanylate cyclase/phosphodiesterase (Paraburkholderia bryophila 376MFSha3.1)
MKSFSAWSRLAWPREHVNLVGVAIALLISSVVLLIYQALSLRASLTDDVSMQASVLAENL
TASAMFGDREATAEILGSLRKVPHVESATVYTPDGELFVRYARPGLRRADYEEGTLENVG
NSRRLSLEDIFVAAPIIHNDRLLGSIVVVAATDAIKMQLAQYGCFLIGASLCSVWIASLV
MKRMRERVSRAEKDLEYLASTDPLTDLPNRRAFYDELKMRLHKASAANKRVALMMVDLDN
FKTVNDTLGHGAGDELLKQVAEALRNVVRPHDLVSRIGGDEFAIVLGPDASRVRARATAG
RVARNLSRPFVLHGIESAVSASVGFSVYPEDTAEIAELVSNADIALYSAKSRGKSIAVEF
QSEMTAEAQRRARIEAELRKALEQDGLDIVYQPQFDCLSGRLLGAEALVRWTHPTEGPIL
PAEFVPIAENSDLIVALGRWVLWRACRDAANWNAGKNAGVHVAVNISARQLRTEGFTDEV
CTALKKSGLPASLLELELTESQLMSNMSVGIQAMQELRAAGVRLSLDDFGTGYSSLSYLQ
SFPVHSIKIDRSFICPLPNGGQPIVTAIISMAHSFGLLVVAEGVEYPAQLEWLCDARCDV
VQGFLTGRPMRLEQLLTIIRAEEEQKDTRSRTPVAPRPHRVPTA