Annotation: Tetratricopeptide (TPR) repeat
These analyses and tools can help you predict a protein's function, but be skeptical.
For enzymes, over 10% of annotations from KEGG or SEED are probably incorrect.
For other types of proteins, the error rates may be much higher.
MetaCyc and Swiss-Prot have low error rates,
but the best hits in these databases are often quite distant,
so this protein's function may not be the same.
TIGRFam has low error rates.
Finally, many experimentally-characterized proteins are not in any of these databases.
To find relevant papers, use PaperBLAST.
Protein Families and Features
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716
PF13432: TPR_16 "
amino acids 66 to 121 (56 residues), 18.3 bits, see alignment
2e-06
amino acids 94 to 153 (60 residues), 29.6 bits, see alignment
6.1e-10
amino acids 129 to 187 (59 residues), 34.1 bits, see alignment
2.4e-11
amino acids 162 to 224 (63 residues), 36.2 bits, see alignment
E=5.3e-12
amino acids 195 to 257 (63 residues), 30 bits, see alignment
E=4.5e-10
amino acids 270 to 324 (55 residues), 35.3 bits, see alignment
9.9e-12
amino acids 343 to 391 (49 residues), 31.9 bits, see alignment
1.2e-10
PF13181: TPR_8 "
amino acids 89 to 119 (31 residues), 11.8 bits, see alignment (E = 0.00019)
amino acids 122 to 155 (34 residues), 15.5 bits, see alignment (E = 1.3e-05)
amino acids 156 to 181 (26 residues), 13.8 bits, see alignment (E = 4.4e-05)
amino acids 190 to 222 (33 residues), 25.9 bits, see alignment (E = 5.7e-09)
amino acids 258 to 290 (33 residues), 16.3 bits, see alignment (E = 7.1e-06)
amino acids 292 to 323 (32 residues), 26.3 bits, see alignment (E = 4.4e-09)
PF07719: TPR_2 "
amino acids 122 to 155 (34 residues), 26.6 bits, see alignment (E = 3.4e-09)
amino acids 190 to 222 (33 residues), 28.2 bits, see alignment (E = 1.1e-09)
amino acids 292 to 324 (33 residues), 30.8 bits, see alignment (E = 1.5e-10)
amino acids 360 to 390 (31 residues), 24 bits, see alignment (E = 2.3e-08)
PF07721: TPR_4 "
amino acids 124 to 147 (24 residues), 10.8 bits, see alignment (E = 0.00057)
amino acids 156 to 181 (26 residues), 14.6 bits, see alignment (E = 3.3e-05)
amino acids 190 to 215 (26 residues), 11.1 bits, see alignment (E = 0.00047)
amino acids 258 to 282 (25 residues), 10.3 bits, see alignment (E = 0.00086)
PF13374: TPR_10 "
amino acids 126 to 152 (27 residues), 14.9 bits, see alignment (E = 1.8e-05)
amino acids 194 to 220 (27 residues), 18.7 bits, see alignment (E = 1.2e-06)
amino acids 263 to 288 (26 residues), 17.6 bits, see alignment (E = 2.6e-06)
amino acids 292 to 322 (31 residues), 17.9 bits, see alignment (E = 2e-06)
amino acids 365 to 390 (26 residues), 14.9 bits, see alignment (E = 1.8e-05)
PF13414: TPR_11 "
amino acids 131 to 169 (39 residues), 31.8 bits, see alignment
7.4e-11
amino acids 197 to 234 (38 residues), 30.2 bits, see alignment
2.3e-10
amino acids 268 to 305 (38 residues), 35 bits, see alignment
7.2e-12
amino acids 342 to 373 (32 residues), 29.9 bits, see alignment (E = 2.9e-10)
PF00515: TPR_1 "
amino acids 190 to 223 (34 residues), 29.5 bits, see alignment (E = 3.9e-10)
amino acids 292 to 323 (32 residues), 32.6 bits, see alignment (E = 3.8e-11)
PF13424: TPR_12 "
amino acids 257 to 322 (66 residues), 34.9 bits, see alignment
E=1.2e-11
amino acids 326 to 390 (65 residues), 37.8 bits, see alignment
E=1.4e-12
PF13174: TPR_6 "
amino acids 293 to 323 (31 residues), 12.9 bits, see alignment (E = 0.00012)
Best Hits
KEGG orthology group: None (inferred from 84% identity to
bug:BC1001_4073 )
Predicted SEED Role "FOG: TPR repeat"
Sequence Analysis Tools PaperBLAST (search for papers about homologs of this protein)
Search CDD (the Conserved Domains Database, which includes COG and superfam)
Compare to protein structures
Predict protein localization: PSORTb (Gram-negative bacteria)
Predict transmembrane helices and signal peptides: Phobius
Check the current SEED with FIGfam search
Find homologs in fast.genomics or the ENIGMA genome browser
Find the best match in UniProt
Protein Sequence (716 amino acids) >H281DRAFT_03248 Tetratricopeptide (TPR) repeat (Paraburkholderia bryophila 376MFSha3.1)
MNLTQTLASSITELNQQAMALYSADQFAAALSTVMPVIERDESALDGAAIHAMADALNLA
GASSCRLGEPDDAERYWRRCLRMMPGYVEVYESLGELLKARGRLSAAKAIYRQLIVLQPG
HADAHNQLGAVLYAQGYHEDAEASYRRALVLRPDHAEAHYNHGVVLHALQRLDEAEAAYR
ETLVRLPAHAEAHNNLGNVLMDLGRVAQADAAYREALTIRPQYPEALNNLAGALKAAQRL
TEAELACRLALTMRPDYAEAHVNLGATLTDLQRLPEAEAAYRKAIALRADYAEAYYNLGI
TLFKLERLTEAAEAYREAVRLRPGIAPAHNNLGCVLRLLDCLPEAVECFEQALSVHPDLA
EAHYNLGATLAQLKRWPGAESAYRRALELRADYGEARFGLATLLLGMGRFDEGWRLYECR
YQLAGFVHRHSAQRLRCPQWQGDALSGRSLLVWQEDGLGDMLQFSRYFALLKAQGAANVA
FACAPALHRLMARVDGVDAVLDHDTAVARASAYHCWTSLLSAPLHLRTAVDTIPRPVRLS
VEPSLVERWQTVIDALPPGRRIGLVWKGNAKHHNDANRSIPSLATLAPLWSVDGVSFVSL
QKGQGEDEARNPPAGQPLLHLGSMVTDLADSAAIVGQLDLVICVDTSIAHLAASLGKPCW
VVLPEKDVDWRWMHERSDSPWYPHTLRLFRRERGEEWAVVVERVRQACVARFGVRN