Protein Info for H281DRAFT_03220 in Paraburkholderia bryophila 376MFSha3.1
Annotation: 4-hydroxy-tetrahydrodipicolinate synthase
These analyses and tools can help you predict a protein's function, but be skeptical. For enzymes, over 10% of annotations from KEGG or SEED are probably incorrect. For other types of proteins, the error rates may be much higher. MetaCyc and Swiss-Prot have low error rates, but the best hits in these databases are often quite distant, so this protein's function may not be the same. TIGRFam has low error rates. Finally, many experimentally-characterized proteins are not in any of these databases. To find relevant papers, use PaperBLAST.
Protein Families and Features
Best Hits
Swiss-Prot: 72% identical to KDADA_AZOBR: L-2-keto-3-deoxyarabonate dehydratase (araD) from Azospirillum brasilense
KEGG orthology group: K01714, dihydrodipicolinate synthase [EC: 4.2.1.52] (inferred from 97% identity to bug:BC1001_4105)Predicted SEED Role
"L-2-keto-3-deoxyarabonate dehydratase (EC 4.2.1.43)" in subsystem L-Arabinose utilization (EC 4.2.1.43)
MetaCyc Pathways
- L-arabinose degradation III (5/6 steps found)
- L-lyxonate degradation (2/3 steps found)
- superpathway of pentose and pentitol degradation (21/42 steps found)
KEGG Metabolic Maps
- Ascorbate and aldarate metabolism
- Biosynthesis of alkaloids derived from ornithine, lysine and nicotinic acid
- Lysine biosynthesis
Isozymes
Compare fitness of predicted isozymes for: 4.2.1.52
Use Curated BLAST to search for 4.2.1.43 or 4.2.1.52
Sequence Analysis Tools
PaperBLAST (search for papers about homologs of this protein)
Search CDD (the Conserved Domains Database, which includes COG and superfam)
Predict protein localization: PSORTb (Gram-negative bacteria)
Predict transmembrane helices and signal peptides: Phobius
Check the current SEED with FIGfam search
Find homologs in fast.genomics or the ENIGMA genome browser
See A0A2Z5MGH1 at UniProt or InterPro
Protein Sequence (310 amino acids)
>H281DRAFT_03220 4-hydroxy-tetrahydrodipicolinate synthase (Paraburkholderia bryophila 376MFSha3.1) MNRPVNPAAMRGVFPVAPTIFDDAGQLDLEGQKRCIDFMIDAGSNGLCILANFSEQFALS DEERETLMHVVLEHVAGRVPVIVTTTHFSSHQCAERSRRAQAAGAAMVMIMPPYHGATIR IGERGIEEFYRTVSDAIDIPIMIQDAPVSGTPLSAPFLARMANEIEHVSYFKIEVPQAAN KLRELIQLGGDAIVGPWDGEEAITLMADLDAGATGSMTGGGYADGIRLIVDAYAAGDTEA AAAHYQQWLPLINYENRQGGLASCKALMKEGGVIRSDAVRHPLPAMHPATREGLLKIARR LDPLVLRWAH