Protein Info for H281DRAFT_03153 in Paraburkholderia bryophila 376MFSha3.1

Annotation: two component transcriptional regulator, LuxR family

These analyses and tools can help you predict a protein's function, but be skeptical. For enzymes, over 10% of annotations from KEGG or SEED are probably incorrect. For other types of proteins, the error rates may be much higher. MetaCyc and Swiss-Prot have low error rates, but the best hits in these databases are often quite distant, so this protein's function may not be the same. TIGRFam has low error rates. Finally, many experimentally-characterized proteins are not in any of these databases. To find relevant papers, use PaperBLAST.

Protein Families and Features

1 50 100 150 215 PF00072: Response_reg" amino acids 12 to 122 (111 residues), 92.1 bits, see alignment E=3.9e-30 PF08281: Sigma70_r4_2" amino acids 150 to 194 (45 residues), 27.4 bits, see alignment 3.2e-10 PF00196: GerE" amino acids 153 to 207 (55 residues), 59.9 bits, see alignment E=2.1e-20

Best Hits

Swiss-Prot: 38% identical to DEVR_MYCTO: DNA-binding transcriptional activator DevR/DosR (devR) from Mycobacterium tuberculosis (strain CDC 1551 / Oshkosh)

KEGG orthology group: None (inferred from 96% identity to bug:BC1001_4178)

Predicted SEED Role

"Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain"

Sequence Analysis Tools

PaperBLAST (search for papers about homologs of this protein)

Search CDD (the Conserved Domains Database, which includes COG and superfam)

Search structures

Predict protein localization: PSORTb (Gram-negative bacteria)

Predict transmembrane helices and signal peptides: Phobius

Check the current SEED with FIGfam search

Find homologs in fast.genomics or the ENIGMA genome browser

See A0A2Z5MGB4 at UniProt or InterPro

Protein Sequence (215 amino acids)

>H281DRAFT_03153 two component transcriptional regulator, LuxR family (Paraburkholderia bryophila 376MFSha3.1)
MNDISHAAARLILVDDHPLVRDGLRARLEAVRNIEVVGEAGNAQEALALAESHEPHLVLM
DVGMNGMNGIALAGMFHERFPAIRVLMLSMHDNLEYVTQAVRAGASGYVLKDSPATEIIQ
AIGAVLDGKTYFSAGLGARLIHASAMQSPVERLTPRERDILDALAEGLSSKQIAQRNDLS
VRTVETHRLNLKRKLDIEGQAELIKFAVENRRASR