Protein Info for H281DRAFT_03072 in Paraburkholderia bryophila 376MFSha3.1

Annotation: Signal transduction histidine kinase

These analyses and tools can help you predict a protein's function, but be skeptical. For enzymes, over 10% of annotations from KEGG or SEED are probably incorrect. For other types of proteins, the error rates may be much higher. MetaCyc and Swiss-Prot have low error rates, but the best hits in these databases are often quite distant, so this protein's function may not be the same. TIGRFam has low error rates. Finally, many experimentally-characterized proteins are not in any of these databases. To find relevant papers, use PaperBLAST.

Protein Families and Features

1 50 100 150 200 250 300 350 400 447 signal peptide" amino acids 1 to 29 (29 residues), see Phobius details transmembrane" amino acids 30 to 33 (4 residues), see Phobius details amino acids 157 to 177 (21 residues), see Phobius details PF00672: HAMP" amino acids 176 to 225 (50 residues), 34.6 bits, see alignment 2e-12 PF02518: HATPase_c" amino acids 331 to 436 (106 residues), 82.7 bits, see alignment E=2.6e-27

Best Hits

KEGG orthology group: None (inferred from 91% identity to bug:BC1001_4259)

Predicted SEED Role

"Integral membrane sensor signal transduction histidine kinase (EC 2.7.13.3), glucose catabolism cluster" (EC 2.7.13.3)

Isozymes

Compare fitness of predicted isozymes for: 2.7.13.3

Use Curated BLAST to search for 2.7.13.3

Sequence Analysis Tools

PaperBLAST (search for papers about homologs of this protein)

Search CDD (the Conserved Domains Database, which includes COG and superfam)

Search structures

Predict protein localization: PSORTb (Gram-negative bacteria)

Predict transmembrane helices and signal peptides: Phobius

Check the current SEED with FIGfam search

Find homologs in fast.genomics or the ENIGMA genome browser

See A0A2Z5MMD1 at UniProt or InterPro

Protein Sequence (447 amino acids)

>H281DRAFT_03072 Signal transduction histidine kinase (Paraburkholderia bryophila 376MFSha3.1)
MSLISSLHWPRTLFARLTVILFFGLASAQALSFWLTMTERDQTMTNVMMGYIEREVASSV
ALLDHLPANERAQWLPRLARRSYEFMLGPGVSGGPVDANLSARVARSIDEGIGTNYPLTV
NAVPGDRERLQVHLKLTDGTPLTIDMRPMSGAPLSRWLPLVLLLQLVVLLGCCWLAVRTA
TRPLHDLAVAADALGPDLKAARLSESGPSEVARAARAFNAMQERIAMYVTERMQILAAIS
HDLQTPITRMRLRVDMMDAESEGIKLRQDLQEMEALVKEGVTYARTLHGATELPCRIDPD
ALFDSLVCDYVDAGQAVSLQGRFGMPLMTRPQALRRIVGNLVDNALKFGGSAEIDVTMLP
GGQASVAVLDRGPGIPADSLEDVFQPFYRLEASRNRQTGGTGLGLAIARQLALAMDATLG
LHNRAGGGLEARLTLRNLVMASPAAVA