Protein Info for H281DRAFT_02891 in Paraburkholderia bryophila 376MFSha3.1

Annotation: transcriptional regulator, propionate catabolism operon regulatory protein

These analyses and tools can help you predict a protein's function, but be skeptical. For enzymes, over 10% of annotations from KEGG or SEED are probably incorrect. For other types of proteins, the error rates may be much higher. MetaCyc and Swiss-Prot have low error rates, but the best hits in these databases are often quite distant, so this protein's function may not be the same. TIGRFam has low error rates. Finally, many experimentally-characterized proteins are not in any of these databases. To find relevant papers, use PaperBLAST.

Protein Families and Features

1 50 100 150 200 250 300 350 400 450 500 550 600 666 TIGR02329: propionate catabolism operon regulatory protein PrpR" amino acids 14 to 662 (649 residues), 552.7 bits, see alignment E=4.2e-170 PF06506: PrpR_N" amino acids 39 to 204 (166 residues), 146.5 bits, see alignment E=2.4e-46 PF00158: Sigma54_activat" amino acids 336 to 504 (169 residues), 229.5 bits, see alignment E=7.9e-72 PF14532: Sigma54_activ_2" amino acids 337 to 508 (172 residues), 69.1 bits, see alignment E=1.9e-22 PF07728: AAA_5" amino acids 360 to 479 (120 residues), 29.6 bits, see alignment E=2.6e-10 PF02954: HTH_8" amino acids 633 to 661 (29 residues), 34.1 bits, see alignment (E = 7.6e-12)

Best Hits

KEGG orthology group: K02688, transcriptional regulator, propionate catabolism operon regulatory protein (inferred from 84% identity to bug:BC1001_3718)

Predicted SEED Role

"Propionate catabolism operon regulatory protein PrpR" in subsystem Methylcitrate cycle

Sequence Analysis Tools

PaperBLAST (search for papers about homologs of this protein)

Search CDD (the Conserved Domains Database, which includes COG and superfam)

Search structures

Predict protein localization: PSORTb (Gram-negative bacteria)

Predict transmembrane helices and signal peptides: Phobius

Check the current SEED with FIGfam search

Find homologs in fast.genomics or the ENIGMA genome browser

Find the best match in UniProt

Protein Sequence (666 amino acids)

>H281DRAFT_02891 transcriptional regulator, propionate catabolism operon regulatory protein (Paraburkholderia bryophila 376MFSha3.1)
MSTFAPSLVNADSGRPGIALVSISRLESLCETIAPRYAGRARFFSIREGYGSAVTALQAY
VDVGSVDVVLAAGSNGAYLRDHLSVPVVMVKVNGFDVLSAITRATTVWPNEPIGLVLHET
ISHELADLSGWLSVGLKQRAYRSVDEVRTAVRDLAAEGCRVIIGPGMACDLAQQEGLESV
FLYSLGAVEEAFERSVELARVSRQKESKRVRLNTIVAHLRDGVAAFDDAGRLEAVNPAML
ELLGLDRDRDVSAQLARTVGPWLRKALQGDGALDERIEQIGERSLIVNCVPIVEQGARSG
VVVTGQDALVAQRIDRSLRTSQRPRHLVARHRLDDLIGESAALERVRRLARAGAAHDVTV
LLTGESGTGKELVAQGIHNASPRRGNPFVAFNCAALPEGLIESELFGHEEGAFTGARRGG
KPGLFEMAHTGTIFLDEIGEMPPALQSRLLRVLQEREVMKLGSGRATPVDVRVIAATHRD
LHALVDEGGFRADLYFRLNLLQIELPPLRERRADVALLARHLLSRDALQYGLSEAASDRV
LQFLTPLFERYAWPGNVRELENLLARAAIYLGDAASEQRVDPDGNVQRDLLALFPEFSRM
EQAGGNGRLVRISADAATPGAARAAPSRDDALEALARCGGNRAAASRALGIGRTTLWRLL
KADGAR