Protein Info for H281DRAFT_02860 in Paraburkholderia bryophila 376MFSha3.1

Annotation: cobalt-precorrin-5B (C1)-methyltransferase

These analyses and tools can help you predict a protein's function, but be skeptical. For enzymes, over 10% of annotations from KEGG or SEED are probably incorrect. For other types of proteins, the error rates may be much higher. MetaCyc and Swiss-Prot have low error rates, but the best hits in these databases are often quite distant, so this protein's function may not be the same. TIGRFam has low error rates. Finally, many experimentally-characterized proteins are not in any of these databases. To find relevant papers, use PaperBLAST.

Protein Families and Features

1 50 100 150 200 250 300 362 PF01888: CbiD" amino acids 12 to 271 (260 residues), 305.9 bits, see alignment E=1e-95 TIGR00312: cobalamin biosynthesis protein CbiD" amino acids 19 to 336 (318 residues), 214.5 bits, see alignment E=9.6e-68

Best Hits

Swiss-Prot: 92% identical to CBID_PARPJ: Cobalt-precorrin-5B C(1)-methyltransferase (cbiD) from Paraburkholderia phytofirmans (strain DSM 17436 / LMG 22146 / PsJN)

KEGG orthology group: K02188, cobalamin biosynthesis protein CbiD (inferred from 93% identity to bug:BC1001_3688)

Predicted SEED Role

"Cobalt-precorrin-6 synthase, anaerobic" in subsystem Cobalamin synthesis or Coenzyme B12 biosynthesis

MetaCyc Pathways

Sequence Analysis Tools

PaperBLAST (search for papers about homologs of this protein)

Search CDD (the Conserved Domains Database, which includes COG and superfam)

Search structures

Predict protein localization: PSORTb (Gram-negative bacteria)

Predict transmembrane helices and signal peptides: Phobius

Check the current SEED with FIGfam search

Find homologs in fast.genomics or the ENIGMA genome browser

See A0A2Z5MN19 at UniProt or InterPro

Protein Sequence (362 amino acids)

>H281DRAFT_02860 cobalt-precorrin-5B (C1)-methyltransferase (Paraburkholderia bryophila 376MFSha3.1)
MRDETPEQPAPLRSGYTTGSCATATSLAAARLLLAGVVSEVAEIVLPKGQHVPMPLVFCR
LTDDGAEAGTIKDAGDDPDVTHGAVVFARVRLVPEPGVVFRAGPGVGTVTRAGLTLAVGE
PAINPVPRKMMSEHLAELAAEHAYGGGFEVTIGVEDGEALALKTMNPRLGIVGGLSILGT
TGIVRPFSCSAYIASIHQGIDVARANGYMHLAACTGNASEDAMRSHYALPDIALIEMGDF
VGAVLKHMKRAPVERLSICGGFGKLSKLAAGHLDLHSRNSSIDLERLAAWAAEQGADDAL
QSAIRAANTSQQAVALAHAEQVPLGDIVCAHALAVAREIVPPQVNVEMFAIDRAGKLIGV
AR