Protein Info for H281DRAFT_02842 in Paraburkholderia bryophila 376MFSha3.1

Annotation: diguanylate cyclase (GGDEF) domain-containing protein

These analyses and tools can help you predict a protein's function, but be skeptical. For enzymes, over 10% of annotations from KEGG or SEED are probably incorrect. For other types of proteins, the error rates may be much higher. MetaCyc and Swiss-Prot have low error rates, but the best hits in these databases are often quite distant, so this protein's function may not be the same. TIGRFam has low error rates. Finally, many experimentally-characterized proteins are not in any of these databases. To find relevant papers, use PaperBLAST.

Protein Families and Features

1 50 100 150 200 250 300 350 386 transmembrane" amino acids 36 to 55 (20 residues), see Phobius details amino acids 175 to 198 (24 residues), see Phobius details TIGR00254: diguanylate cyclase (GGDEF) domain" amino acids 212 to 375 (164 residues), 145 bits, see alignment E=9e-47 PF00990: GGDEF" amino acids 215 to 372 (158 residues), 146.9 bits, see alignment E=2.3e-47

Best Hits

KEGG orthology group: None (inferred from 82% identity to bug:BC1001_3667)

Predicted SEED Role

"diguanylate cyclase/phosphodiesterase (GGDEF & EAL domains) with PAS/PAC sensor(s)" in subsystem Bacterial hemoglobins

Sequence Analysis Tools

PaperBLAST (search for papers about homologs of this protein)

Search CDD (the Conserved Domains Database, which includes COG and superfam)

Search structures

Predict protein localization: PSORTb (Gram-negative bacteria)

Predict transmembrane helices and signal peptides: Phobius

Check the current SEED with FIGfam search

Find homologs in fast.genomics or the ENIGMA genome browser

See A0A2Z5MJZ7 at UniProt or InterPro

Protein Sequence (386 amino acids)

>H281DRAFT_02842 diguanylate cyclase (GGDEF) domain-containing protein (Paraburkholderia bryophila 376MFSha3.1)
MAAEVSKTPTRIPETLFALPRESGRANGWRLTPGPATVAVASLLCLLIGLLYLALQIRTV
FADQVKQEYAGLVLEAVERAETARARVGVWDQVPHAHDAAAEGYGQARAELTRRLASLAA
LVNASPANAPRIPSSVLLPDATFGEMDRLLGDASSYWHTQRDTYSADMRKRITGIAHMLI
AVAALLFCLLITALGMYAKRNRQLAGQSHEFKHAALHDPMTGLANRRKLFAALEEAAAQA
SMSVSPRKMAVLYVDLDGFKKVNDSRGHRVGDEFLVAVSRRFRESVRKEDVVARIGGDEF
AVLVQEFAEQEELRQIAQRLIACVARTDEQMGMGMVRASIGIASYPDLVDDYCRLVAAAD
EAMYRVKRSGKNGFAFASRASEARVG