Protein Info for H281DRAFT_02823 in Paraburkholderia bryophila 376MFSha3.1

Annotation: PAS/PAC sensor hybrid histidine kinase

These analyses and tools can help you predict a protein's function, but be skeptical. For enzymes, over 10% of annotations from KEGG or SEED are probably incorrect. For other types of proteins, the error rates may be much higher. MetaCyc and Swiss-Prot have low error rates, but the best hits in these databases are often quite distant, so this protein's function may not be the same. TIGRFam has low error rates. Finally, many experimentally-characterized proteins are not in any of these databases. To find relevant papers, use PaperBLAST.

Protein Families and Features

1 50 100 150 200 250 300 350 400 450 500 550 600 650 700 750 777 PF00989: PAS" amino acids 12 to 113 (102 residues), 27.5 bits, see alignment E=1.1e-09 amino acids 284 to 391 (108 residues), 35.3 bits, see alignment E=4.3e-12 TIGR00229: PAS domain S-box protein" amino acids 13 to 130 (118 residues), 36.5 bits, see alignment E=2.4e-13 amino acids 181 to 277 (97 residues), 39.7 bits, see alignment E=2.4e-14 amino acids 284 to 401 (118 residues), 71.9 bits, see alignment E=2.7e-24 PF08448: PAS_4" amino acids 15 to 110 (96 residues), 27 bits, see alignment E=1.8e-09 amino acids 203 to 274 (72 residues), 24.8 bits, see alignment E=8.9e-09 amino acids 286 to 395 (110 residues), 47.6 bits, see alignment E=7.1e-16 PF13426: PAS_9" amino acids 20 to 117 (98 residues), 30.8 bits, see alignment E=1.2e-10 amino acids 290 to 393 (104 residues), 49.3 bits, see alignment E=2.1e-16 PF08447: PAS_3" amino acids 180 to 264 (85 residues), 57 bits, see alignment E=7.7e-19 amino acids 306 to 387 (82 residues), 26 bits, see alignment E=3.6e-09 PF00512: HisKA" amino acids 415 to 480 (66 residues), 53.8 bits, see alignment E=6.6e-18 PF02518: HATPase_c" amino acids 527 to 638 (112 residues), 98.1 bits, see alignment E=1.7e-31 PF00072: Response_reg" amino acids 660 to 770 (111 residues), 74.1 bits, see alignment E=4e-24

Best Hits

KEGG orthology group: None (inferred from 84% identity to bpy:Bphyt_5296)

Predicted SEED Role

"Chemotaxis protein methyltransferase CheR (EC 2.1.1.80)" in subsystem Bacterial Chemotaxis (EC 2.1.1.80)

Isozymes

Compare fitness of predicted isozymes for: 2.1.1.80

Use Curated BLAST to search for 2.1.1.80

Sequence Analysis Tools

PaperBLAST (search for papers about homologs of this protein)

Search CDD (the Conserved Domains Database, which includes COG and superfam)

Search structures

Predict protein localization: PSORTb (Gram-negative bacteria)

Predict transmembrane helices and signal peptides: Phobius

Check the current SEED with FIGfam search

Find homologs in fast.genomics or the ENIGMA genome browser

See A0A2Z5MKE5 at UniProt or InterPro

Protein Sequence (777 amino acids)

>H281DRAFT_02823 PAS/PAC sensor hybrid histidine kinase (Paraburkholderia bryophila 376MFSha3.1)
MQSTDRHLPLADALFEHAACGLVVTDTDGRIVRANATFCEWIGYGAAELTSGISLQDLLT
TGGKVFYQTHWAPLLQMQGSVAEVKLSMLHRDGHTVPTLLNAVRRVHGDQSYIEVAVLIV
ADRHKYEQELVLARRNAEASVAAHQRAQRELQESRDVLSLAMRGARMGAWSHEPKTGKFW
WSRELEALAGYAEGRLAITTRGFFELIHPGDLLALNEAVDHAVRTRDDYVAEFRFLHASG
DWCWMEGRGRATYDERGEPLTVYGLGIDITERKQAQTVLLRQAAIFEHLSDAIVITDLRG
NITDFNVGGERMLGYRLRDILGKHVSIFHPPEDALRIRREVFASLGAYGTWRGELPFARR
DGSRGVCETVVKPLANERGDIYGAVSINRDITERRHAEQQLTRLNAELSNADRRKDEFLA
TLAHELRNPLAPMRNVLEILRAKEFSDPQLNWSRDVFSRQLQHMTHLVDDLLEVSRITQG
KLELRKQRLELARAMQSAVEAARAIVQASDHRLSVTLSPEPLFLDADPTRLSQMILNLLN
NAAKYTPPGGSISLTAHREGNQAVITVRDSGIGIPREHLNSVFEMFSQLAPALDRSQGGL
GIGLALVRGLAELHGGTVAAFSNGPGAGSEFVIRLPLSSSADAPADSTEPDKPPAAGLRI
VIVDDNADAADSLAMVLELEGHQVRTASDGVAGLAVIAEFAPQAVILDIGLPLLNGYEVA
RRVRNDYPDAGIRLIAVTGWGQQQDKQTAVEAGFDHHFTKPVDPSELQRVLSGHQVK