Protein Info for H281DRAFT_02800 in Paraburkholderia bryophila 376MFSha3.1

Annotation: 6-phosphogluconate dehydrogenase (decarboxylating)

These analyses and tools can help you predict a protein's function, but be skeptical. For enzymes, over 10% of annotations from KEGG or SEED are probably incorrect. For other types of proteins, the error rates may be much higher. MetaCyc and Swiss-Prot have low error rates, but the best hits in these databases are often quite distant, so this protein's function may not be the same. TIGRFam has low error rates. Finally, many experimentally-characterized proteins are not in any of these databases. To find relevant papers, use PaperBLAST.

Protein Families and Features

1 50 100 150 200 250 300 345 TIGR00872: 6-phosphogluconate dehydrogenase (decarboxylating)" amino acids 1 to 336 (336 residues), 410.7 bits, see alignment E=1.7e-127 PF03446: NAD_binding_2" amino acids 2 to 152 (151 residues), 129.9 bits, see alignment E=1.5e-41 PF03807: F420_oxidored" amino acids 3 to 92 (90 residues), 22 bits, see alignment E=3.2e-08 PF00393: 6PGD" amino acids 184 to 212 (29 residues), 36.2 bits, see alignment (E = 7.2e-13) amino acids 233 to 332 (100 residues), 30.5 bits, see alignment E=3.9e-11

Best Hits

KEGG orthology group: K00033, 6-phosphogluconate dehydrogenase [EC: 1.1.1.44] (inferred from 93% identity to bug:BC1001_3630)

Predicted SEED Role

"6-phosphogluconate dehydrogenase, decarboxylating (EC 1.1.1.44)" in subsystem Pentose phosphate pathway (EC 1.1.1.44)

MetaCyc Pathways

KEGG Metabolic Maps

Isozymes

Compare fitness of predicted isozymes for: 1.1.1.44

Use Curated BLAST to search for 1.1.1.44

Sequence Analysis Tools

PaperBLAST (search for papers about homologs of this protein)

Search CDD (the Conserved Domains Database, which includes COG and superfam)

Search structures

Predict protein localization: PSORTb (Gram-negative bacteria)

Predict transmembrane helices and signal peptides: Phobius

Check the current SEED with FIGfam search

Find homologs in fast.genomics or the ENIGMA genome browser

See A0A2Z5MHY4 at UniProt or InterPro

Protein Sequence (345 amino acids)

>H281DRAFT_02800 6-phosphogluconate dehydrogenase (decarboxylating) (Paraburkholderia bryophila 376MFSha3.1)
MQLGMIGLGRMGADMVRRLTKGGQQCIAYDVQPAAVERLGQEGVLGASSLEDLVAKLEKP
RAVWLMVPAAVVDGTLDKLLPLLEPGDIVIDGGNSYYHDDIRRGAQLAERKLHYVDVGTS
GGVAGRERGYCLMIGGEAEVVQRLEPIFSTLAPGAAAAPATPGRTEGSSTAEQGFLHCGP
IGAGHFVKMVHNGIEYGLMAAYAEGLNILRHADAGKHARDADAETSPLRRPELYQYDLNL
ADIAEVWRRGSVIGSWLLDLIAGSLVGDADLKNYAGRVSDSGEGRWTMAAAVDEGVPAPV
LSAALFGRFSSRGEADFANRVLSAMRHDFGGHAEKPPAPSGSQQG