Protein Info for H281DRAFT_02781 in Paraburkholderia bryophila 376MFSha3.1

Annotation: Response regulator c-di-GMP phosphodiesterase, RpfG family, contains REC and HD-GYP domains

These analyses and tools can help you predict a protein's function, but be skeptical. For enzymes, over 10% of annotations from KEGG or SEED are probably incorrect. For other types of proteins, the error rates may be much higher. MetaCyc and Swiss-Prot have low error rates, but the best hits in these databases are often quite distant, so this protein's function may not be the same. TIGRFam has low error rates. Finally, many experimentally-characterized proteins are not in any of these databases. To find relevant papers, use PaperBLAST.

Protein Families and Features

1 50 100 150 200 250 300 350 400 463 PF00072: Response_reg" amino acids 32 to 141 (110 residues), 85 bits, see alignment E=8.5e-28 PF13487: HD_5" amino acids 209 to 375 (167 residues), 123.8 bits, see alignment E=1.3e-39 PF08668: HDOD" amino acids 223 to 273 (51 residues), 23.5 bits, see alignment 6.9e-09 PF01966: HD" amino acids 224 to 338 (115 residues), 23.7 bits, see alignment E=9.9e-09

Best Hits

KEGG orthology group: None (inferred from 90% identity to bug:BC1001_3613)

Predicted SEED Role

"Response regulator"

Sequence Analysis Tools

PaperBLAST (search for papers about homologs of this protein)

Search CDD (the Conserved Domains Database, which includes COG and superfam)

Search structures

Predict protein localization: PSORTb (Gram-negative bacteria)

Predict transmembrane helices and signal peptides: Phobius

Check the current SEED with FIGfam search

Find homologs in fast.genomics or the ENIGMA genome browser

Find the best match in UniProt

Protein Sequence (463 amino acids)

>H281DRAFT_02781 Response regulator c-di-GMP phosphodiesterase, RpfG family, contains REC and HD-GYP domains (Paraburkholderia bryophila 376MFSha3.1)
MSDLQATGNSTIPADPCIQALNAGTSPVPTLLLVDDEPGVISSLKRLLRPLKYEVLSANS
GAEALTLLESAQVDVIISDMRMPNMDGAEFLSRSRAVAPDTIRILLTGYSEVEAVVRAVN
EGHVYHYLHKPWDDQDLLLTVQRALEQLALQRKAERLTLLLQEQNDKLSSFNMELEREVH
ARTEEIRQTVMFLEGAEHDLKSNFLTMVKVCANMVEMRCGLPGHSARIGETARQIGAALG
LSDYACNELLMAGLLHGIGKLFLPDALLKTPIAKLQPQEAKLYQLHPLHGQMALTPVSQL
STVQTMIRHQYERYDGRGTPDGLVGGLIPLGARVLALARDAEDLRIGVIAPQKMSDAQII
STVRAQTGIRYDPAIAEKYIELLMQHAELTPEGVPDRVDASNLKEGMKLADDLRTSRGTL
LMTKGKVLSAEQVAQIRRFEIHEGEPFVILVERATDARKAQAA