Protein Info for H281DRAFT_02675 in Paraburkholderia bryophila 376MFSha3.1

Annotation: carbon-monoxide dehydrogenase small subunit

These analyses and tools can help you predict a protein's function, but be skeptical. For enzymes, over 10% of annotations from KEGG or SEED are probably incorrect. For other types of proteins, the error rates may be much higher. MetaCyc and Swiss-Prot have low error rates, but the best hits in these databases are often quite distant, so this protein's function may not be the same. TIGRFam has low error rates. Finally, many experimentally-characterized proteins are not in any of these databases. To find relevant papers, use PaperBLAST.

Protein Families and Features

1 50 100 173 PF00111: Fer2" amino acids 9 to 58 (50 residues), 33.6 bits, see alignment E=4.5e-12 PF13085: Fer2_3" amino acids 40 to 82 (43 residues), 30.8 bits, see alignment E=3.9e-11 PF01799: Fer2_2" amino acids 76 to 149 (74 residues), 109.8 bits, see alignment E=8.4e-36

Best Hits

Swiss-Prot: 59% identical to CDHC_PSEU3: Caffeine dehydrogenase subunit gamma (cdhC) from Pseudomonas sp. (strain CBB1)

KEGG orthology group: K03518, carbon-monoxide dehydrogenase small subunit [EC: 1.2.99.2] (inferred from 65% identity to tro:trd_0578)

MetaCyc: 61% identical to 1-testosterone hydratase/dehydrogenase gamma subunit (Steroidobacter denitrificans)
RXN-21494 [EC: 1.17.99.11]; 1.17.99.11 [EC: 1.17.99.11]; 1.17.99.11 [EC: 1.17.99.11]

Predicted SEED Role

"Carbon monoxide dehydrogenase small chain (EC 1.2.99.2)" in subsystem CO Dehydrogenase (EC 1.2.99.2)

MetaCyc Pathways

KEGG Metabolic Maps

Isozymes

Compare fitness of predicted isozymes for: 1.2.99.2

Use Curated BLAST to search for 1.17.99.11 or 1.2.99.2

Sequence Analysis Tools

PaperBLAST (search for papers about homologs of this protein)

Search CDD (the Conserved Domains Database, which includes COG and superfam)

Search structures

Predict protein localization: PSORTb (Gram-negative bacteria)

Predict transmembrane helices and signal peptides: Phobius

Check the current SEED with FIGfam search

Find homologs in fast.genomics or the ENIGMA genome browser

See A0A2Z5MJ71 at UniProt or InterPro

Protein Sequence (173 amino acids)

>H281DRAFT_02675 carbon-monoxide dehydrogenase small subunit (Paraburkholderia bryophila 376MFSha3.1)
METRTVRVVVNGTAYEREVESRRMLGDFLRHDLELTGTHYGCEHGVCGACTVLIEGRTAR
ACLTLAAQVNGRSLTTVEGLAHADGTLNELQKAFTETHALQCGFCTPGMLMTLTELLNET
DSPSESEIREAITGNLCRCTGYQPIVAAALLAAQRIRDQRAAASTTPAAHATE