Protein Info for H281DRAFT_02633 in Paraburkholderia bryophila 376MFSha3.1

Annotation: beta-galactosidase

These analyses and tools can help you predict a protein's function, but be skeptical. For enzymes, over 10% of annotations from KEGG or SEED are probably incorrect. For other types of proteins, the error rates may be much higher. MetaCyc and Swiss-Prot have low error rates, but the best hits in these databases are often quite distant, so this protein's function may not be the same. TIGRFam has low error rates. Finally, many experimentally-characterized proteins are not in any of these databases. To find relevant papers, use PaperBLAST.

Protein Families and Features

1 50 100 150 200 250 300 350 400 450 500 550 600 657 PF02449: Glyco_hydro_42" amino acids 6 to 392 (387 residues), 459.7 bits, see alignment E=1.4e-141 PF08532: Glyco_hydro_42M" amino acids 408 to 601 (194 residues), 113.2 bits, see alignment E=1.8e-36 PF08533: Glyco_hydro_42C" amino acids 609 to 655 (47 residues), 29.9 bits, see alignment 5.5e-11

Best Hits

Swiss-Prot: 55% identical to BGAL_THETH: Beta-galactosidase from Thermus thermophilus

KEGG orthology group: None (inferred from 62% identity to bgl:bglu_2g04070)

Predicted SEED Role

"Beta-galactosidase (EC 3.2.1.23)" in subsystem Galactosylceramide and Sulfatide metabolism or Lactose and Galactose Uptake and Utilization or Lactose utilization (EC 3.2.1.23)

MetaCyc Pathways

KEGG Metabolic Maps

Isozymes

Compare fitness of predicted isozymes for: 3.2.1.23

Use Curated BLAST to search for 3.2.1.23

Sequence Analysis Tools

PaperBLAST (search for papers about homologs of this protein)

Search CDD (the Conserved Domains Database, which includes COG and superfam)

Search structures

Predict protein localization: PSORTb (Gram-negative bacteria)

Predict transmembrane helices and signal peptides: Phobius

Check the current SEED with FIGfam search

Find homologs in fast.genomics or the ENIGMA genome browser

See A0A2Z5MJL2 at UniProt or InterPro

Protein Sequence (657 amino acids)

>H281DRAFT_02633 beta-galactosidase (Paraburkholderia bryophila 376MFSha3.1)
MQLGVCYYPEQWPDTMWADDARRMVDMGITHVRIAEFAWSRMEPRAGVYEWAWLDRAIDT
LAGAGLKIVLGTPTASPPRWLVEAIPDMLPVRADGTTWNYGSRRHYDICSEPYRRECVRI
TEAMAARYGAHPAVVAWQTDNELGCHETVPSYSNAARQRFRGWLARRYETVGELNTRWGN
VFWSMEYPSFDSIELPNVTPTDANPIHLLDFRRFMSDEVTSFHREQAEVVRRHAPHADVL
HNFMGFFTTFDHYRFASNGSIDVATWDSYPIARTEVIALAETDKARYARTGHPDVSAFDH
DRYRGIGQGRFWVMEQEAGPVNWAPWNPVPAPGMVRLWAYEAFAHGAELVSYFRWRQAPF
AQEQMHSGLHLPDNTPSPGGREVARAAQEIAKSAELSALAQSGPAGRAPVALVFDYETQW
MFEIQRHAKDFDYQTLAFEYYRTLREMSLDVDIVSAHADLDGYALIVVPGLAVLPPGFVD
TIRRSSAQWVIGPRTGSKTLDFAIPSELPPGPLQTLLPFKVLEVDSLRPSLQPSTTLGGV
SGIALHWREHLETRDGVEVLARFDDGWPAVVARDRVRYASAWFDPPLHRALLEAAARDAS
LNPVHLPEGVRIRRRGPLTFAFNFGAQAVEAPAPANARFVLGSRTLGTADVCVWTQA