Protein Info for H281DRAFT_02463 in Paraburkholderia bryophila 376MFSha3.1

Annotation: choline dehydrogenase

These analyses and tools can help you predict a protein's function, but be skeptical. For enzymes, over 10% of annotations from KEGG or SEED are probably incorrect. For other types of proteins, the error rates may be much higher. MetaCyc and Swiss-Prot have low error rates, but the best hits in these databases are often quite distant, so this protein's function may not be the same. TIGRFam has low error rates. Finally, many experimentally-characterized proteins are not in any of these databases. To find relevant papers, use PaperBLAST.

Protein Families and Features

1 50 100 150 200 250 300 350 400 450 500 561 PF00732: GMC_oxred_N" amino acids 6 to 301 (296 residues), 202.2 bits, see alignment E=1.5e-63 TIGR01810: choline dehydrogenase" amino acids 7 to 538 (532 residues), 912.9 bits, see alignment E=3.2e-279 PF05199: GMC_oxred_C" amino acids 394 to 528 (135 residues), 134.6 bits, see alignment E=5.8e-43

Best Hits

Swiss-Prot: 93% identical to BETA_PARPJ: Oxygen-dependent choline dehydrogenase (betA) from Paraburkholderia phytofirmans (strain DSM 17436 / LMG 22146 / PsJN)

KEGG orthology group: None (inferred from 96% identity to bgf:BC1003_5871)

MetaCyc: 80% identical to choline dehydrogenase (Pseudomonas aeruginosa)
Choline dehydrogenase. [EC: 1.1.99.1]

Predicted SEED Role

"Choline dehydrogenase (EC 1.1.99.1)" in subsystem Choline and Betaine Uptake and Betaine Biosynthesis (EC 1.1.99.1)

MetaCyc Pathways

KEGG Metabolic Maps

Isozymes

Compare fitness of predicted isozymes for: 1.1.99.1

Use Curated BLAST to search for 1.1.99.1

Sequence Analysis Tools

PaperBLAST (search for papers about homologs of this protein)

Search CDD (the Conserved Domains Database, which includes COG and superfam)

Search structures

Predict protein localization: PSORTb (Gram-negative bacteria)

Predict transmembrane helices and signal peptides: Phobius

Check the current SEED with FIGfam search

Find homologs in fast.genomics or the ENIGMA genome browser

See A0A2Z5MJT5 at UniProt or InterPro

Protein Sequence (561 amino acids)

>H281DRAFT_02463 choline dehydrogenase (Paraburkholderia bryophila 376MFSha3.1)
MTSNEYDYIVVGAGSAGNVLASRLTEDADVTVLLLEAGGPDYRFDFRTQMPAALAYPLQG
RRYNWAYETDPEPHMNNRRMECGRGKGLGGSSLINGMCYIRGNALDYDGWATRRGLENWT
YLDCLPYFRKAETRDAGPNAYHGGDGPVHVTTSKPGNNPLFAAMVEAGVQAGFPRTDDLN
GYQQEGFGPMDRTVTPNGRRASTARGYLDRARARANLTIVTHALSDRVLFSGKRAVGVAY
QHEGATVNAHARREVLVCSGAIASPQLLQRSGVGRSTWLRELDIPVVHDLPGVGENLQDH
LEMYIQYECKEPVSLYPALQWWNQPAIGLEWMLNGTGIGASNQFEAGGFIRTRDDDLWPN
IQYHFLPVAINYNGSNAIKMHGFQAHVGSMRSPSRGRVKLTSRDPAAHPSILFNYMADPL
DWREFRDGIRITREIMRQPALDRYRGRELNPGAELTTDAELDSFVRARAETAFHPSCSCK
MGYDDMAVVDNEGRVHGLQALRVVDASIMPIITTGNLNAPTIMLAEKIADRIRGREPLAR
VDTPYFVANGAPARKRERATV